2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. IGF-I (24-41)

IGF-I (24-41)  (Synonyms: Insulin-like Growth Factor I (24-41))

Cat. No.: HY-P1777 Purity: 99.11%
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IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development.

For research use only. We do not sell to patients.

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IGF-I (24-41) Chemical Structure

IGF-I (24-41) Chemical Structure

CAS No. : 135861-49-3

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1 mg USD 250 In-stock
5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of IGF-I (24-41):

IGF-I (24-41) Related Antibodies

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Description

IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development[1][2][3].

In Vivo

IGF-I (24-41) (ICV; 200 ng dose; 2 µL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)[2]
Dosage: 200 ng dose; 2 µL
Administration: ICV; postnatal days (PND) 2, 4, and 7
Result: Increased the rate of ultrasonic calls of the pups measured on PND8.
Molecular Weight

2017.16

Formula

C88H133N27O28
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr
Sequence Shortening

YFNKPTGYGSSSRRAPQT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (24.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4957 mL 2.4787 mL 4.9575 mL
5 mM 0.0991 mL 0.4957 mL 0.9915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (49.57 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4957 mL 2.4787 mL 4.9575 mL 12.3937 mL
5 mM 0.0991 mL 0.4957 mL 0.9915 mL 2.4787 mL
10 mM 0.0496 mL 0.2479 mL 0.4957 mL 1.2394 mL
15 mM 0.0330 mL 0.1652 mL 0.3305 mL 0.8262 mL
20 mM 0.0248 mL 0.1239 mL 0.2479 mL 0.6197 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IGF-I (24-41) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IGF-I (24-41)135861-49-3Insulin-like Growth Factor I (24-41)IGF-1RInsulin-like growth factor-1 receptorendocrineparacrineautocrineneuronsglial cellsgrowth hormoneGHInhibitorinhibitorinhibit

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