2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. IGF family
  5. Insulin-like Growth Factor I (IGF-1)

Insulin-like Growth Factor I (IGF-1)

Recombinant Protein Expression Service

Insulin-like Growth Factor I (IGF-1)

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Insulin-like growth factors (IGFs) function as both tissue growth factors and circulating hormones. They actively participate in mammalian development and growth. The IGF family is comprised of insulin and two factors similar to insulin termed IGF-1 and IGF-2. IGF-I and IGF-II are single-chain polypeptides and evolutionarily conserved. The two molecules have 62% homology in their amino acid sequences and their structures resemble the structure of proinsulin. IGFs need a complex system to act, often, it is known as the IGF “axis” system, which should include two IGFs type as IGF-I and IGF-II, two cell-surface receptors such as IGF-receptor type 1 (IGF-1R) and IGF-receptor type 2 (IGF-2R), specific to each IGFs type with tyrosine kinase activity and a family of IGF binding proteins (IGFBPs) . IGFs play an important role in regulating cell proliferation, differentiation, apoptosis, and transformation.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7018
    IGF-I/IGF-1 Protein, Human (70a.a)

    rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

    		Human E. coli
    IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.
  • HY-P70783
    LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)

    Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

    		Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free. and E51R, , , , mutation. The total length of LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is 70 a.a., with molecular weight of ~11.0 kDa.
  • HY-P70783G
    GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)

    Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

    		Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free. The total length of GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is 70 a.a., with molecular weight of ~11 kDa.
  • HY-P73136
    IGF-I/IGF-1 Protein, Human (HEK293, hFc)

    Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1

    		Human HEK293
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (HEK293, hFc) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IGF-I/IGF-1 Protein, Human (HEK293, hFc) is 70 a.a., with molecular weight of 35-40 kDa.
  • HY-P70788
    IGF-I/IGF-1 Protein, Human (G49-A118)

    Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    		Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (G49-A118) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by E. coli , with tag free.
  • HY-P700093AF
    Animal-Free IGF-I/IGF-1 Protein, Human (His)

    Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    		Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.
  • HY-P700478
    IGF-I/IGF-1 Protein, Human (P. pastoris, N-His)

    Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    		Human P. pastoris
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by P. pastoris , with N-6*His labeled tag.
  • HY-P7070
    IGF-I/IGF-1 Protein, Mouse

    rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

    		Mouse E. coli
    IGF-I/IGF-1 Protein, Mouse is a mitogenic cytokine.
  • HY-P701241
    IGF-I Protein, Salmon

    IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C

    		Others E. coli
    IGF-I protein is similar to insulin and exerts effective growth-promoting activity as a ligand of IGF1R. Binding to the α subunit of IGF1R activates intrinsic tyrosine kinase, triggering autophosphorylation of the β subunit. IGF-I Protein, Salmon is the recombinant IGF-I protein, expressed by E. coli , with tag free. The total length of IGF-I Protein, Salmon is 70 a.a., with molecular weight of ~8 kDa.
  • HY-P70698
    IGF-I/IGF-1 Protein, Mouse (His)

    IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C

    		Mouse E. coli
    IGF-I/IGF-1 Protein, Mouse (His) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. IGF1 also mediates neuroprotective mechanism.
  • HY-P7203
    IGF-I/IGF-1 Protein, Rat

    rRtIGF-I; Somatomedin C; IGF1; Mechano growth factor

    		Rat E. coli
    IGF-I/IGF-1 Protein, Rat has somatomedin activity and ability to potently promote neuronal survival.
  • HY-P70698A
    IGF-I/IGF-1 Protein, Mouse (N-His)

    IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C

    		Mouse E. coli
    The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. IGF-I/IGF-1 Protein, Mouse (N-His) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P70698AF
    Animal-Free IGF-I/IGF-1 Protein, Mouse (His)

    rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

    		Mouse E. coli
    The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. Animal-Free IGF-I/IGF-1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.
  • HY-P74843
    IGF-I/IGF-1 Protein, Mouse (P.pastoris)

    Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1

    		Mouse P. pastoris
    IGF-I/IGF-1 Protein, part of the insulin family, is highlighted. IGF-I/IGF-1 Protein, Mouse (P.pastoris) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by P. pastoris , with tag free.
  • HY-P700241AF
    Animal-Free IGF-I Protein, Pig (His)

    Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1

    		Pig E. coli
    The IGF-I protein is structurally similar to insulin and has excellent growth-promoting activity. As a potential physiological regulator, it affects [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Animal-Free IGF-I Protein, Pig (His) is the recombinant pig-derived animal-FreeIGF-I protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IGF-I Protein, Pig (His) is 70 a.a., with molecular weight of ~8.59 kDa.
Cat. No. Product Name Effect Purity