IGF-I (24-41) (TFA) (Synonyms: Insulin-like Growth Factor I (24-41) (TFA))

Cat. No.: HY-P1777A: FAQs
Data Sheet Handling Instructions

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IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development.

For research use only. We do not sell to patients.

IGF-I (24-41) (TFA) Chemical Structure

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Other Forms of IGF-I (24-41) (TFA):

IGF-I (24-41) Get quote

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Purity & Documentation
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Description

In Vivo

IGF-I (24-41) TFA (ICV; 200 ng dose; 2 µL; postnatal days (PND) 2, 4, and 7) regulates somatic growth and behavioral development^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)^[2]
Dosage:	ICV
Administration:	200 ng dose; 2 µL; postnatal days (PND) 2, 4, and 7
Result:	Increased the rate of ultrasonic calls of the pups measured on PND8.

Molecular Weight

2017.16 (free acid)

Formula

C₈₈H₁₃₃N₂₇O₂₈.xC₂HF₃O₂

Sequence

Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr

Sequence Shortening

YFNKPTGYGSSSRRAPQT

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. [Content Brief]

[2]. D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. [Content Brief]

[3]. Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. [Content Brief]

IGF-I (24-41) (TFA) Related Classifications

Metabolic Disease Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IGF-I (24-41) (TFA)Insulin-like Growth Factor I (24-41) (TFA)IGF-1RInsulin-like growth factor-1 receptorendocrineparacrineautocrineneuronsglial cellsgrowth hormoneGHInhibitorinhibitorinhibit

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