IITR08367 

IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H⁺ reverse transporter activity. ^[1].

IITR08367 (0-50 μM) concentration-dependently enhances the activity of Fosfomycin against AbaF-expressing strain of Escherichia coli. A concentration of 50 μM can increase the postantibiotic effect of Fosfomycin by 30 min^[1].
IITR08367 (25 μM; 16 min) disrupts the H⁺ gradient across the membrane, ultimately inhibiting the H⁺ gradient-driven efflux pump without causing membrane damage^[1].
IITR08367 (100 μM; 12 h) and Fosfomycin (64 mg/L) in combination can inhibit A. baumannii RPTC-15 growth^[1].
IITR08367 (100 μM) eliminates the Biofilm Forming Ability of A. baumannii with and without the addition of Fosfomycin^[1].
IITR08367 (12.5-200 μM) is not toxic to erythrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IITR08367 (i.p.; 30 mg/kg; every 12 h for 54 h ) co-administered with Fosfomycin to Urinary tract infections mice shows significant improvement in the damage caused by A. baumannii RPTC-15, with tissue ultrastructure similar to that of uninfected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

274.44

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Saini M, et al. Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition. ACS Infect Dis. 2024 Apr 1.  [Content Brief]