2. Anti-infection
  3. HCV
  4. IMAB027

IMAB027  (Synonyms: ASP1650)

Cat. No.: HY-P99413 Purity: ≥95.0%
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IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines.

For research use only. We do not sell to patients.

CAS No. : 1650599-68-0

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1 mg USD 450 In-stock
5 mg USD 1170 In-stock
10 mg USD 1870 In-stock
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Based on 1 publication(s) in Google Scholar

IMAB027 Related Antibodies

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Description

IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric

IC50 & Target

CLDN6[1]
In Vitro

IMAB027 specifically binds to CLDN6 rather than other closely related family members, such as Claudins 3, 4, and 9[1].
IMAB027 induces target-selective antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) in CLDN6+ ovarian and testicular cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMAB027 Related Antibodies
In Vivo

IMAB027 reduces tumor growth and increases overall survival in xenografted mouse tumors with human CLDN6+ cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[IMAB027]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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IMAB027 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMAB0271650599-68-0ASP1650IMAB 027IMAB-027ASP 1650ASP-1650HCVHepatitis C virusInhibitorinhibitorinhibit

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