Imipramine-d₄ hydrochloride

Name: Imipramine-d 4 hydrochloride
Brand: MedChemExpress
SKU: HY-B1490S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1490S Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions

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Imipramine-d₄ (hydrochloride) is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

For research use only. We do not sell to patients.

Imipramine-d<sub>4</sub> hydrochloride Chemical Structure

Imipramine-d₄ hydrochloride Chemical Structure

CAS No. : 61361-33-9

Size	Price	Stock	Quantity
1 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Imipramine-d₄ hydrochloride:

Imipramine hydrochloride In-stock
Imipramine-d₄ Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.89

Formula

C₁₉H₂₁D₄ClN₂

CAS No.

61361-33-9

Unlabeled CAS

113-52-0

Appearance

Solid

Color

White to off-white

SMILES

CN(C)CCCN1C2=C([2H])C=C([2H])C=C2CCC3=CC([2H])=CC([2H])=C31.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (311.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1163 mL	15.5817 mL	31.1633 mL
5 mM	0.6233 mL	3.1163 mL	6.2327 mL
10 mM	0.3116 mL	1.5582 mL	3.1163 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (255 KB) HNMR (1469 KB) RP-HPLC (788 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292. [Content Brief]

[3]. Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. [Content Brief]

[4]. Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. [Content Brief]

[5]. Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20. [Content Brief]

[6]. Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1163 mL	15.5817 mL	31.1633 mL	77.9083 mL
	5 mM	0.6233 mL	3.1163 mL	6.2327 mL	15.5817 mL
	10 mM	0.3116 mL	1.5582 mL	3.1163 mL	7.7908 mL
	15 mM	0.2078 mL	1.0388 mL	2.0776 mL	5.1939 mL
	20 mM	0.1558 mL	0.7791 mL	1.5582 mL	3.8954 mL
	25 mM	0.1247 mL	0.6233 mL	1.2465 mL	3.1163 mL
	30 mM	0.1039 mL	0.5194 mL	1.0388 mL	2.5969 mL
	40 mM	0.0779 mL	0.3895 mL	0.7791 mL	1.9477 mL
	50 mM	0.0623 mL	0.3116 mL	0.6233 mL	1.5582 mL
	60 mM	0.0519 mL	0.2597 mL	0.5194 mL	1.2985 mL
	80 mM	0.0390 mL	0.1948 mL	0.3895 mL	0.9739 mL
	100 mM	0.0312 mL	0.1558 mL	0.3116 mL	0.7791 mL