2. Neuronal Signaling
  3. Serotonin Transporter Dopamine Transporter
  4. Indatraline hydrochloride

Indatraline hydrochloride  (Synonyms: Lu 19-005)

Cat. No.: HY-110019
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Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.

For research use only. We do not sell to patients.

Indatraline hydrochloride Chemical Structure

Indatraline hydrochloride Chemical Structure

CAS No. : 96850-13-4

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Based on 1 publication(s) in Google Scholar

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Indatraline hydrochloride Related Antibodies

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Description

Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1].

IC50 & Target

monoamine transporter[1]
In Vitro

Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1].
Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1].
Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indatraline hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0~5 μM
Incubation Time: 24 hours
Result: Made the concentration-dependent conversion of LC3.

Immunofluorescence[1]

Cell Line: EGFP-LC3 stable cells
Concentration: 1~10 μM
Incubation Time: 24 hours
Result: EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm.
In Vivo

Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

328.66

Formula

C16H16Cl3N
CAS No.
SMILES

CN[C@@H]1C[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indatraline hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indatraline96850-13-4Lu 19-005Serotonin TransporterDopamine Transporter5-HTTSERTSLC6A4DATSLC6A3non-selectivemonoaminetransporterblocksreuptakeneurotransmittersdopamineserotoninnorepinephrineInhibitorinhibitorinhibit

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