cis-Indatraline hydrochloride (Synonyms: cis-Lu 19-005)

Name: cis-Indatraline hydrochloride
Brand: MedChemExpress
SKU: HY-110019A
Rating: 4.5 (1 reviews)

Cat. No.: HY-110019A Purity: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

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cis-Indatraline (cis-Lu 19-005) hydrochloride is an active compound. cis-Indatraline (cis-Lu 19-005) hydrochloride can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

cis-Indatraline hydrochloride Chemical Structure

CAS No. : 86939-08-4

Size	Price	Stock	Quantity
5 mg	USD 264	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 422	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 840	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1345	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1980	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of cis-Indatraline hydrochloride:

Indatraline hydrochloride Get quote

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Purity & Documentation
References
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Description

cis-Indatraline (cis-Lu 19-005) hydrochloride is an active compound. cis-Indatraline (cis-Lu 19-005) hydrochloride can be used for the research of neurodegenerative diseases^[1].

Molecular Weight

328.66

Formula

C₁₆H₁₆Cl₃N

CAS No.

86939-08-4

Appearance

Solid

Color

White to off-white

SMILES

CN[C@@H]1C[C@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (152.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0427 mL	15.2133 mL	30.4266 mL
5 mM	0.6085 mL	3.0427 mL	6.0853 mL
10 mM	0.3043 mL	1.5213 mL	3.0427 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (15.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (15.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (257 KB) HNMR (155 KB) RP-HPLC (160 KB) LCMS (146 KB)

Handling Instructions (2659 KB)

References

[1]. Peter T. Lansbury, et al. Treatment of neurodegenerative diseases using indatraline analogs. Patent. WO2009036275A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0427 mL	15.2133 mL	30.4266 mL	76.0665 mL
	5 mM	0.6085 mL	3.0427 mL	6.0853 mL	15.2133 mL
	10 mM	0.3043 mL	1.5213 mL	3.0427 mL	7.6066 mL
	15 mM	0.2028 mL	1.0142 mL	2.0284 mL	5.0711 mL
	20 mM	0.1521 mL	0.7607 mL	1.5213 mL	3.8033 mL
	25 mM	0.1217 mL	0.6085 mL	1.2171 mL	3.0427 mL
	30 mM	0.1014 mL	0.5071 mL	1.0142 mL	2.5355 mL
	40 mM	0.0761 mL	0.3803 mL	0.7607 mL	1.9017 mL
	50 mM	0.0609 mL	0.3043 mL	0.6085 mL	1.5213 mL
	60 mM	0.0507 mL	0.2536 mL	0.5071 mL	1.2678 mL
	80 mM	0.0380 mL	0.1902 mL	0.3803 mL	0.9508 mL
	100 mM	0.0304 mL	0.1521 mL	0.3043 mL	0.7607 mL

cis-Indatraline hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-Indatraline86939-08-4cis-Lu 19-005Othersactive compoundneurodegenerative diseasesInhibitorinhibitorinhibit

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cis-Indatraline hydrochloride (Synonyms: cis-Lu 19-005)

Customer Review

Other Forms of cis-Indatraline hydrochloride:

cis-Indatraline hydrochloride Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

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Complete Stock Solution Preparation Table

cis-Indatraline hydrochloride Related Classifications

Keywords:

Your Recently Viewed Products:

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