Inophyllum B (Synonyms: (+)-Inophyllum B)

Cat. No.: HY-142074: FAQs
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Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica.

For research use only. We do not sell to patients.

Inophyllum B Chemical Structure

CAS No. : 41135-06-2

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Description

IC₅₀ & Target^[1]

HIV-1

1.4 μM (IC₅₀)

Reverse Transcriptase

38 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
MOLT-4	IC₅₀	1.4 μM Compound: 2a (inophyllum B)	Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay	[PMID: 7506311]
MOLT-4	IC₅₀	55 μM Compound: 2a (inophyllum B)	Tested for cytotoxicity in Molt-4 cells by XTT assay Tested for cytotoxicity in Molt-4 cells by XTT assay	[PMID: 7506311]

Molecular Weight

404.46

Formula

C₂₅H₂₄O₅

CAS No.

41135-06-2

SMILES

O[C@@H]1C2=C(O[C@@H]([C@H]1C)C)C(C=CC(C)(O3)C)=C3C(C(C4=CC=CC=C4)=C5)=C2OC5=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patil AD, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec 24;36(26):4131-8. [Content Brief]

Inophyllum B Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inophyllum B41135-06-2(+)-Inophyllum BReverse TranscriptaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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