inS3-54-A26

Cat. No.: HY-118081: FAQs
Data Sheet Handling Instructions

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inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC₅₀ of 4.0 μM for non-cancerous lung fibroblasts.

For research use only. We do not sell to patients.

inS3-54-A26 Chemical Structure

CAS No. : 328998-77-2

Size	Price	Stock	Quantity
1 mg	USD 190	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	USD 450	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	USD 650	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC₅₀ of 4.0 μM for non-cancerous lung fibroblasts^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1299	IC₅₀	3.4 μM Compound: A26	Cytotoxicity against human H1299 cells assessed as inhibition of cell survival after 72 hrs by SRB method Cytotoxicity against human H1299 cells assessed as inhibition of cell survival after 72 hrs by SRB method	[PMID: 30145375]

Molecular Weight

414.88

Formula

C₂₅H₁₉ClN₂O₂

CAS No.

328998-77-2

SMILES

CC(NC1=CC=C(C=C1)N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C=C4)Cl)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. [Content Brief]

inS3-54-A26 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

inS3-54-A26328998-77-2STATNon-cancerous lung fibroblastTumourInhibitorinhibitorinhibit

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