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Intralipid 20% is a safe fat emulsion that can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response.

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Intralipid 20% Chemical Structure

Intralipid 20% Chemical Structure

CAS No. : 68890-65-3

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Based on 1 publication(s) in Google Scholar

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Intralipid 20% Related Antibodies

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Description

Intralipid 20% is a safe fat emulsion that can be used as a nutritional supplement. Intralipid 20% effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response[1][2].

In Vitro

Intralipid 20% (0-0.2 mg/mL) specifically protects immune cells from paclitaxel, but has no effect on tumor cells[1].
Intralipid 20% (0-0.2 mg/mL, 3 days) promotes polarisation of M0, M1 and M2 macrophages to an M1-like phenotype[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Intralipid 20% Related Antibodies
In Vivo

Intralipid (2 g/kg) does not affect phagocytosis and may promote macrophage polarization to the M1 phenotype, as observed in breast cancer tumor sections from Balb/c mice[1].
Intralipid pretreatment promotes the accumulation of paclitaxel in tumour tissue and induces higher levels of apoptosis in tumour cells. Increased distribution of paclitaxel in mouse RES organs and enhanced inhibition of tumour growth[1].
Intralipid (5 mL/kg) is more effective than cyclosporin-A in protecting the heart from I/R injury in SD rats, reducing the size of myocardial infarction by approximately 40%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Solid-Liquid Mixture

Color

White to off-white

SMILES

[Intralipid 20%]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation
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Intralipid 20% Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Intralipid 20%68890-65-3Othersfat emulsionnutritional supplementmitochondrial permeabilityinnate immune responseInhibitorinhibitorinhibit

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Intralipid 20%
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