2. PI3K/Akt/mTOR PROTAC
  3. Akt PROTACs
  4. INY-05-040

INY-05-040 is a AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines, with anti-cancer activity.

For research use only. We do not sell to patients.

INY-05-040 Chemical Structure

INY-05-040 Chemical Structure

CAS No. : 2503018-29-7

Size Price Stock Quantity
1 mg USD 360 In-stock
5 mg USD 900 In-stock
10 mg USD 1450 In-stock
25 mg USD 2900 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

INY-05-040 Related Antibodies

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

INY-05-040 is a AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines, with anti-cancer activity[1].

Molecular Weight

1026.77

Formula

C55H76ClN9O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CNCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)N=CN=C2[C@@H](C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (97.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9739 mL 4.8696 mL 9.7393 mL
5 mM 0.1948 mL 0.9739 mL 1.9479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9739 mL 4.8696 mL 9.7393 mL 24.3482 mL
5 mM 0.1948 mL 0.9739 mL 1.9479 mL 4.8696 mL
10 mM 0.0974 mL 0.4870 mL 0.9739 mL 2.4348 mL
15 mM 0.0649 mL 0.3246 mL 0.6493 mL 1.6232 mL
20 mM 0.0487 mL 0.2435 mL 0.4870 mL 1.2174 mL
25 mM 0.0390 mL 0.1948 mL 0.3896 mL 0.9739 mL
30 mM 0.0325 mL 0.1623 mL 0.3246 mL 0.8116 mL
40 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.6087 mL
50 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4870 mL
60 mM 0.0162 mL 0.0812 mL 0.1623 mL 0.4058 mL
80 mM 0.0122 mL 0.0609 mL 0.1217 mL 0.3044 mL
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INY-05-040 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INY-05-0402503018-29-7AktPROTACsPKBProtein kinase BAnticancerbreast cancerT47DInhibitorinhibitorinhibit

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