2. PI3K/Akt/mTOR
  3. Akt
  4. Ipatasertib tosylate

Ipatasertib tosylate  (Synonyms: GDC-0068 tosylate; RG7440 tosylate)

Cat. No.: HY-15186C
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Ipatasertib (GDC-0068) (tosylate) is a highly selective ATP-competitive pan-Akt inhibitor with antitumor effects. Ipatasertib (tosylate) prevents colon cancer growth through p53-independent p53 upregulated modulator of apoptosis (PUMA) dependent Apoptosis. Ipatasertib (tosylate) leads to PUMA activation by inhibiting Akt, thereby activating both FoxO3a and NF-κB synchronously that will directly bind to PUMA promoter, up-regulating PUMA transcription and Bax-mediated intrinsic mitochondrial Apoptosis.

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Ipatasertib tosylate Chemical Structure

Ipatasertib tosylate Chemical Structure

CAS No. : 1491138-24-9

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Ipatasertib tosylate Related Antibodies

Top Publications Citing Use of Products

39 Publications Citing Use of MCE Ipatasertib tosylate

WB

    Ipatasertib tosylate purchased from MedChemExpress. Usage Cited in: Front Oncol. 2021 Nov 24:11:766298.  [Abstract]

    Ipatasertib (0.625, 1.25, 5 µM; 24 h) increases the phosphorylation of AKT in MFM-223 FGFR2amp cells.

    Ipatasertib tosylate purchased from MedChemExpress. Usage Cited in: Skelet Muscle. 2021 Mar 15;11(1):6.  [Abstract]

    The western blot analysis and quantification of phosphorylated and all forms of AKT and P70, MyoG, and MyoD, after transfecting miR-1290/miR-NC with or without GDC0068. GDC-0068 inhibits miR-1290-activated phosphorylation of AKT and P70 in C2C12 myoblasts.

    Ipatasertib tosylate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct;180:114145.  [Abstract]

    C2C12 myoblasts were pre-incubated with 2.5 μM GDC-0068 for 30 min then treated with 0.2 μM S-Rg3. After incubation with S-Rg3 for 72 h and 24 h, Western blotting is used to detect levels of Myf5 and myogenin in C2C12 myoblasts after incubation of cells with S-Rg3 for 120 h. GDC-0068 inhibits S-Rg3-activated phosphorylation of Akt and mTOR in C2C12 myoblasts.

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    Description

    Ipatasertib (GDC-0068) (tosylate) is a highly selective ATP-competitive pan-Akt inhibitor with antitumor effects. Ipatasertib (tosylate) prevents colon cancer growth through p53-independent p53 upregulated modulator of apoptosis (PUMA) dependent Apoptosis. Ipatasertib (tosylate) leads to PUMA activation by inhibiting Akt, thereby activating both FoxO3a and NF-κB synchronously that will directly bind to PUMA promoter, up-regulating PUMA transcription and Bax-mediated intrinsic mitochondrial Apoptosis[1].

    Molecular Weight

    630.20

    Formula

    C31H40ClN5O5S
    CAS No.
    SMILES

    O=S(O)(C1=CC=C(C=C1)C)=O.ClC2=CC=C([C@@H](CNC(C)C)C(N3CCN(C4=C([C@H](C)C[C@H]5O)C5=NC=N4)CC3)=O)C=C2
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Ipatasertib tosylate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ipatasertib1491138-24-9GDC-0068RG7440GDC0068GDC 0068RG 7440RG-7440AktPKBProtein kinase Bantitumorcolon cancerApoptosisPUMAFoxO3a and NF-κB synchronouslyInhibitorinhibitorinhibit

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