IR-1061 

IR-1061 is a near infrared fluorescent organic dye for in vivo bimodal imaging^[1][2].

The emission peak of IR-1061 is approximately at 1100 nm, the main absorption peak is at 1064 nm, and there is a slight shoulder peak at 890 nm^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IR-1061 exhibits excellent performance in in vivo imaging experiments on mice. Bimodal imaging is performed by a single injection of the PLP-D probe containing IR-1061. In OTN-NIR imaging, signals can be observed 30 seconds after injection. Blood vessels and the liver are visualized first, and the signals remains stable within 300 seconds after injection. Most of the signals accumulates in the liver and spleen 150 minutes later. In MRI, imaging startes 30 minutes after injection, and signal changes in regions such as the liver and bladder can be observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

749.13

C₄₄H₃₄BClF₄S₂

155614-01-0

Solid

Brown to black

[F-][B+3]([F-])([F-])[F-].ClC1=C(/C=C/C2=CC(C3=CC=CC=C3)=[S+]C(C4=CC=CC=C4)=C2)CCC/C1=C/C=C5C=C(C6=CC=CC=C6)SC(C7=CC=CC=C7)=C/5

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Thi Kim Dung Doan, et al. The influence of Gd-DOTA conjugating ratios to PLGA-PEG micelles encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging. Biomater Sci. 2022 Mar 2;10(5):1217-1230.  [Content Brief]

  [2]. Doan TKD, et al. The effect of Gd-DOTA locations within PLGA-b-PEG micelle encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging. Biomater Sci. 2022 Oct 25;10(21):6244-6257.  [Content Brief]