IRAK4-IN-27

Cat. No.: HY-155574: FAQs
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IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC₅₀ of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study.

For research use only. We do not sell to patients.

IRAK4-IN-27 Chemical Structure

CAS No. : 2626988-86-9

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IRAK1 IRAK4

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IRAK4

8.7 nM (IC₅₀)

In Vitro

IRAK4-IN-27 (Compound 22, 72 h) shows antiproliferative activity against MYD88 L265P DLBCL cell line (OCI-LY10, IC₅₀ = 0.248 μM) and MYD88 WT cell lines (U2932, IC₅₀ = 1.251 μM, and GM00637, IC₅₀ = 1.520 μM) ^[1].
IRAK4-IN-27 (0.5 and 1 μM, 24 and 48 h) induces apoptosis in OCI-LY10 cells^[1].
IRAK4-IN-27 (0.03-3 μM) inhibits phosphorylation of IRAK4 and downstream signaling in OCI-LY10 cells^[1].
IRAK4-IN-27 (0.1 and 0.2 μM, 48 h) in combination with Ibrutinib (HY-10997) inhibits cell growth, but induces apoptosis in OCI-LY10 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	OCI-LY10 cells
Concentration:	0, 0.1, 0.2, 0.5, 1 μM
Incubation Time:	24 and 48 h
Result:	Triggered significant apoptosis after 24 h incubation, with apoptosis rates of 48.3% and 66.8% at the concentration of 0.5 μM and 1 μM, respectively. Induced apoptosis of 67.2% and 92.3% after 48 h incubation at the concentration of 0.5 μM and 1 μM, respectively.

Molecular Weight

430.46

Formula

C₂₃H₂₂N₆O₃

CAS No.

2626988-86-9

SMILES

O=C(C1=COC(C2=CC(N)=NC=C2)=N1)NC3=C(C4=CN(C)N=C4)C=C(OC(C)(C)C5)C5=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen Y, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma. Eur J Med Chem. 2023;256:115453. [Content Brief]

IRAK4-IN-27 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-272626988-86-9IRAKApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinasediffuse large B-cell lymphomaOCI-LY10U2932GM00637apoptosisInhibitorinhibitorinhibit

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