iRGD peptide 1 TFA

Name: iRGD peptide 1 TFA
Brand: MedChemExpress
SKU: HY-P0122B
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0122B Purity: 98.45%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers agents deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

iRGD peptide 1 TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers agents deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity^[1].

In Vitro

iRGD peptide 1 (iRGD) inhibits migration of tumor cells and caused chemorepulsion in vitro in a CendR- and NRP-1-dependent manner. iRGD peptide 1 induces dramatic collapse of cellular processes and partial cell detachment, resulting in the repellent activity. These effects are prominently displayed when the cells are seeded on fibronectin, suggesting a role of CendR in functional regulation of integrins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

iRGD peptide 1 (amino acid sequence: CRGDKGPDC; 4 μmol/kg; intravenous injection; every other day; for 21 days) potently inhibits spontaneous metastasis in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1064.08

Formula

C₃₇H₆₀F₃N₁₃O₁₆S₂

Appearance

Solid

Color

White to off-white

Sequence

Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys

Sequence Shortening

CRGDKGPDC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (93.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (93.98 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9398 mL	4.6989 mL	9.3978 mL
5 mM	0.1880 mL	0.9398 mL	1.8796 mL
10 mM	0.0940 mL	0.4699 mL	0.9398 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.45%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (243 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Kazuki N Sugahara, et al. Tumor-penetrating iRGD Peptide Inhibits Metastasis. Mol Cancer Ther. 2015 Jan;14(1):120-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	0.9398 mL	4.6989 mL	9.3978 mL	23.4945 mL
	5 mM	0.1880 mL	0.9398 mL	1.8796 mL	4.6989 mL
	10 mM	0.0940 mL	0.4699 mL	0.9398 mL	2.3494 mL
	15 mM	0.0627 mL	0.3133 mL	0.6265 mL	1.5663 mL
	20 mM	0.0470 mL	0.2349 mL	0.4699 mL	1.1747 mL
	25 mM	0.0376 mL	0.1880 mL	0.3759 mL	0.9398 mL
	30 mM	0.0313 mL	0.1566 mL	0.3133 mL	0.7831 mL
	40 mM	0.0235 mL	0.1175 mL	0.2349 mL	0.5874 mL
	50 mM	0.0188 mL	0.0940 mL	0.1880 mL	0.4699 mL
	60 mM	0.0157 mL	0.0783 mL	0.1566 mL	0.3916 mL
	80 mM	0.0117 mL	0.0587 mL	0.1175 mL	0.2937 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.