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  4. Isaxonine

Isaxonine acts as a modifier of the surface pH of the bilayer. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery. Isaxonine is a neurotrophic agent.

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Isaxonine Chemical Structure

Isaxonine Chemical Structure

CAS No. : 4214-72-6

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Based on 1 publication(s) in Google Scholar

Isaxonine Related Antibodies

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Description

Isaxonine acts as a modifier of the surface pH of the bilayer[1]. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery[2]. Isaxonine is a neurotrophic agent[3].

In Vitro

Isaxonine has a favourable effect on nerve regeneration. After 8 weeks small type grouping is seen in rats receiving solvent only and large type grouping in rats treated with intraperitoneal Isaxonine. After 10 weeks a checkerboard pattern of the fibre types is observed in the muscles of animals receiving solvent only but fibre type grouping was present in those treated with Isaxonine. Isaxonine prevents synaptic remodelling by suppression of the redundant nerve endings from additional axons, which have regenerated more slowly, in making contact with motor endplates[4].
Isaxonine phosphate induces acute hepatitis which in most cases is reversible after withdrawal of the compound[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isaxonine Related Antibodies
Molecular Weight

137.18

Formula

C7H11N3
CAS No.
Appearance

Liquid (Density: 1.065 g/cm3)

Color

Colorless to light yellow

SMILES

CC(C)NC1=NC=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (728.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2897 mL 36.4485 mL 72.8969 mL
5 mM 1.4579 mL 7.2897 mL 14.5794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

SDS (453 KB)

COA (247 KB) HNMR (245 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.2897 mL 36.4485 mL 72.8969 mL 182.2423 mL
5 mM 1.4579 mL 7.2897 mL 14.5794 mL 36.4485 mL
10 mM 0.7290 mL 3.6448 mL 7.2897 mL 18.2242 mL
15 mM 0.4860 mL 2.4299 mL 4.8598 mL 12.1495 mL
20 mM 0.3645 mL 1.8224 mL 3.6448 mL 9.1121 mL
25 mM 0.2916 mL 1.4579 mL 2.9159 mL 7.2897 mL
30 mM 0.2430 mL 1.2149 mL 2.4299 mL 6.0747 mL
40 mM 0.1822 mL 0.9112 mL 1.8224 mL 4.5561 mL
50 mM 0.1458 mL 0.7290 mL 1.4579 mL 3.6448 mL
60 mM 0.1215 mL 0.6075 mL 1.2149 mL 3.0374 mL
80 mM 0.0911 mL 0.4556 mL 0.9112 mL 2.2780 mL
100 mM 0.0729 mL 0.3645 mL 0.7290 mL 1.8224 mL
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Isaxonine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isaxonine4214-72-6OthersModifiersurface pHnerve regenerationsensory function recoveryNeurotrophic AgentInhibitorinhibitorinhibit

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