Isoallolithocholic acid-d₂  (Synonyms: 3β-Hydroxy-5α-cholanic acid-d₂)

Isoallolithocholic acid-d₂ is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

378.58

C₂₄H₃₈D₂O₃

2410277-69-7

2276-93-9

Solid

White to off-white

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC([2H])([2H])C(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@@](C[C@H](CC4)O)([H])CC3)C

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.  [Content Brief]