2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR
  3. EGFR ERK Akt
  4. Isoprocurcumenol

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes.

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Isoprocurcumenol Chemical Structure

Isoprocurcumenol Chemical Structure

CAS No. : 102130-90-5

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Isoprocurcumenol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].

IC50 & Target

ERK

 

Akt

 

In Vitro

Isoprocurcumenol (10 μM, 0-1 h) increases the phosphorylation of ERK and AKT[3].
Isoprocurcumenol (0-200 μM, 24 or 48 h) induces the proliferation of keratinocytes HaCaT cells[3].
Isoprocurcumenol (1 μM, 1 h) increases the expression of genes related to cell growth and proliferation, such as c-fos, c-jun, c-myc, and egr-1, through activation of the EGFR signaling pathway[3].
Isoprocurcumenol induces cell recovery and wound healing[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isoprocurcumenol Related Antibodies

Western Blot Analysis[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 10 μM
Incubation Time: 10, 30, or 60 min
Result: Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h.

Cell Proliferation Assay[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM
Incubation Time: 24 or 48 h
Result: Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM.

RT-PCR[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 1 μM
Incubation Time: 1 h
Result: Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.
Molecular Weight

234.33

Formula

C15H22O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1CC([C@]2([H])CC[C@](C)(O)[C@@]2([H])C/C1=C(C)\C)=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.4 mg/mL (10.24 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2675 mL 21.3374 mL 42.6749 mL
5 mM 0.8535 mL 4.2675 mL 8.5350 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 95.41%

COA (259 KB) HNMR (212 KB) LCMS (77 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2675 mL 21.3374 mL 42.6749 mL 106.6871 mL
5 mM 0.8535 mL 4.2675 mL 8.5350 mL 21.3374 mL
10 mM 0.4267 mL 2.1337 mL 4.2675 mL 10.6687 mL
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Isoprocurcumenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoprocurcumenol102130-90-5EGFRERKAktEpidermal growth factor receptorErbB-1HER1Extracellular signal regulated kinasesPKBProtein kinase BKeratinocytewound healingCurcuma comosaHaCaT cellsCurcuma zedoariaInhibitorinhibitorinhibit

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