Isoprocurcumenol 

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes^[1][2][3].

Isoprocurcumenol (10 μM, 0-1 h) increases the phosphorylation of ERK and AKT^[3].
Isoprocurcumenol (0-200 μM, 24 or 48 h) induces the proliferation of keratinocytes HaCaT cells^[3].
Isoprocurcumenol (1 μM, 1 h) increases the expression of genes related to cell growth and proliferation, such as c-fos, c-jun, c-myc, and egr-1, through activation of the EGFR signaling pathway^[3].
Isoprocurcumenol induces cell recovery and wound healing^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

234.33

C₁₅H₂₂O₂

102130-90-5

Solid

White to off-white

O=C1CC([C@]2([H])CC[C@](C)(O)[C@@]2([H])C/C1=C(C)\C)=C

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4.  [Content Brief]

  [2]. Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414.  [Content Brief]

  [3]. Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22(22):12579.  [Content Brief]