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  4. Isosorbide dimethyl ether

Isosorbide dimethyl ether  (Synonyms: Dimethyl isosorbide; O,O-Dimethylisosorbide)

Cat. No.: HY-134524 Purity: 99.64%
SDS COA Handling Instructions

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Isosorbide dimethyl ether is a biobased high boiling green solvent. Isosorbide dimethyl ether can be used for sustainable ultrafiltration and microfiltration membrane preparation. Isosorbide dimethyl ether can be used as an excipient, such as solvent, penetration aid. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.

For research use only. We do not sell to patients.

Isosorbide dimethyl ether Chemical Structure

Isosorbide dimethyl ether Chemical Structure

CAS No. : 5306-85-4

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10 g USD 32 In-stock
25 g USD 65 In-stock
50 g USD 95 In-stock
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Description

Isosorbide dimethyl ether is a biobased high boiling green solvent. Isosorbide dimethyl ether can be used for sustainable ultrafiltration and microfiltration membrane preparation. Isosorbide dimethyl ether can be used as an excipient, such as solvent, penetration aid. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Molecular Weight

174.19

Formula

C8H14O4
CAS No.
Appearance

Liquid (Density: 1.15 g/cm3)

Color

Colorless to light yellow

SMILES

[H][C@]1(OC[C@@H]2OC)[C@]2([H])OC[C@H]1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (574.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7409 mL 28.7043 mL 57.4086 mL
5 mM 1.1482 mL 5.7409 mL 11.4817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.64%

SDS (393 KB)

COA (256 KB) HNMR (230 KB) MS (81 KB) GC (179 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7409 mL 28.7043 mL 57.4086 mL 143.5214 mL
5 mM 1.1482 mL 5.7409 mL 11.4817 mL 28.7043 mL
10 mM 0.5741 mL 2.8704 mL 5.7409 mL 14.3521 mL
15 mM 0.3827 mL 1.9136 mL 3.8272 mL 9.5681 mL
20 mM 0.2870 mL 1.4352 mL 2.8704 mL 7.1761 mL
25 mM 0.2296 mL 1.1482 mL 2.2963 mL 5.7409 mL
30 mM 0.1914 mL 0.9568 mL 1.9136 mL 4.7840 mL
40 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
50 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8704 mL
60 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3920 mL
80 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
100 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
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Isosorbide dimethyl ether Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isosorbide dimethyl ether5306-85-4Dimethyl isosorbide O,O-DimethylisosorbideBiochemical Assay Reagentspharmaceutical excipientpharmaceutical auxiliariepharmaceutical ingredientsinactive ingredientsstabilitysolubilityprocessabilityabsorptiondistributionmetabolismand elimination (ADME)Inhibitorinhibitorinhibit

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