2. Membrane Transporter/Ion Channel
  3. CFTR
  4. Ivacaftor-d9

Ivacaftor-d9  (Synonyms: VX-770-d9)

Cat. No.: HY-13017S Purity: 99.83%
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Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

For research use only. We do not sell to patients.

Ivacaftor-d<sub>9</sub> Chemical Structure

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

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1 mg USD 345 In-stock
5 mg USD 690 In-stock
10 mg USD 960 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ivacaftor-d9:

Ivacaftor-d9 Related Antibodies

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Description

Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

In Vivo

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

401.55

Formula

C24H19D9N2O3
CAS No.
Unlabeled CAS

873054-44-5
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (124.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (124.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4904 mL 12.4517 mL 24.9035 mL
5 mM 0.4981 mL 2.4903 mL 4.9807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.4903 mL 12.4517 mL 24.9035 mL 62.2587 mL
5 mM 0.4981 mL 2.4903 mL 4.9807 mL 12.4517 mL
10 mM 0.2490 mL 1.2452 mL 2.4903 mL 6.2259 mL
15 mM 0.1660 mL 0.8301 mL 1.6602 mL 4.1506 mL
20 mM 0.1245 mL 0.6226 mL 1.2452 mL 3.1129 mL
25 mM 0.0996 mL 0.4981 mL 0.9961 mL 2.4903 mL
30 mM 0.0830 mL 0.4151 mL 0.8301 mL 2.0753 mL
40 mM 0.0623 mL 0.3113 mL 0.6226 mL 1.5565 mL
50 mM 0.0498 mL 0.2490 mL 0.4981 mL 1.2452 mL
60 mM 0.0415 mL 0.2075 mL 0.4151 mL 1.0376 mL
80 mM 0.0311 mL 0.1556 mL 0.3113 mL 0.7782 mL
100 mM 0.0249 mL 0.1245 mL 0.2490 mL 0.6226 mL
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Ivacaftor-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivacaftor-d91413431-07-8VX-770-d9CFTRCystic fibrosis transmembrane conductance regulatorcystic fibrosismodulatorInhibitorinhibitorinhibit

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