2. Autophagy PROTAC
  3. PROTACs LRRK2
  4. JH-XII-03-02

JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research.

For research use only. We do not sell to patients.

JH-XII-03-02 Chemical Structure

JH-XII-03-02 Chemical Structure

CAS No. : 2415900-86-4

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Based on 1 publication(s) in Google Scholar

JH-XII-03-02 Related Antibodies

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Description

JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1].

Molecular Weight

853.92

Formula

C43H51N9O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1(CC1)OC2=CC=C(C3=C2)NN=C3C4=NC=NC(N5CCN(C(CCOCCOCCOCCOCCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)=O)CC5)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (117.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1711 mL 5.8553 mL 11.7107 mL
5 mM 0.2342 mL 1.1711 mL 2.3421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1711 mL 5.8553 mL 11.7107 mL 29.2767 mL
5 mM 0.2342 mL 1.1711 mL 2.3421 mL 5.8553 mL
10 mM 0.1171 mL 0.5855 mL 1.1711 mL 2.9277 mL
15 mM 0.0781 mL 0.3904 mL 0.7807 mL 1.9518 mL
20 mM 0.0586 mL 0.2928 mL 0.5855 mL 1.4638 mL
25 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1711 mL
30 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9759 mL
40 mM 0.0293 mL 0.1464 mL 0.2928 mL 0.7319 mL
50 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.5855 mL
60 mM 0.0195 mL 0.0976 mL 0.1952 mL 0.4879 mL
80 mM 0.0146 mL 0.0732 mL 0.1464 mL 0.3660 mL
100 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2928 mL
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JH-XII-03-02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-XII-03-022415900-86-4PROTACsLRRK2Leucine-rich repeat kinase 2LRRK2 degraderPROTACParkinson's Disease (PD)Inhibitorinhibitorinhibit

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