2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Androgen Receptor MAGL
  4. JJH260

JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively.

For research use only. We do not sell to patients.

JJH260 Chemical Structure

JJH260 Chemical Structure

CAS No. : 1831135-30-8

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1 mg USD 210 In-stock
5 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

JJH260 Related Antibodies

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Description

JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

IC50 & Target

0.50 μM (AIG1) and 0.57 μM (FAHFA) in HEK293T cells [1]
In Vitro

JJH260 (30 min) inhibits ADTRP, FP-Rh labeling of hAIG1, and the 9-PAHSA hydrolysis activity of hAIG1, in HEK293T, with the IC50 of 0.5 and 0.57μM[1].
JJH260 (5 μM, 4 h) inhibits FAHFA hydrolysis in LNCaP cells and human T-cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JJH260 Related Antibodies
Molecular Weight

568.06

Formula

C29H34ClN5O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C1=CC=C(C(N2CCN(C3C2)C(N(C3=O)OC(N4CCC(CC4)CCC5=CC=C(C=C5)Cl)=O)=O)=O)C=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.25 mg/mL (11.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7604 mL 8.8019 mL 17.6038 mL
5 mM 0.3521 mL 1.7604 mL 3.5208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7604 mL 8.8019 mL 17.6038 mL 44.0094 mL
5 mM 0.3521 mL 1.7604 mL 3.5208 mL 8.8019 mL
10 mM 0.1760 mL 0.8802 mL 1.7604 mL 4.4009 mL
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JJH260 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JJH2601831135-30-8JJH 260JJH-260Androgen ReceptorMAGLMonoacylglycerol lipaseLNCaPhuman B cellsFAHFAlipid metabolismInhibitorinhibitorinhibit

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