1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. JMV6944

JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704).

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JMV6944 Chemical Structure

JMV6944 Chemical Structure

CAS No. : 2871774-93-3

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Description

JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704)[1].

Molecular Weight

518.71

Formula

C30H38N4O2S

CAS No.
SMILES

O=S(NC1=CC=C(N(CC2=CC=CC=C2)C(CCCCCCCN)=N3)C3=C1)(C4=C(C)C=C(C)C=C4C)=O

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JMV6944
Cat. No.:
HY-162738
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