2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. JNJ 10329670

JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation.

For research use only. We do not sell to patients.

JNJ 10329670 Chemical Structure

JNJ 10329670 Chemical Structure

CAS No. : 400797-24-2

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JNJ 10329670 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1].

IC50 & Target[1]

cathepsin S

34 nM (Ki)

In Vitro

JNJ 10329670 (0-100 μM) inhibits cathepsin S and thereby block the proteolysis of the invariant chain in human B cell lines[1].
JNJ 10329670 (0-10 μM) blocks proliferation of T cells in response to both antigens, but less so to the nonspecific T cell mitogen phytohemagglutinin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ 10329670 Related Antibodies
Molecular Weight

651.14

Formula

C30H34ClF3N6O3S
CAS No.
SMILES

FC(F)(F)C1=CC=C(C=C1)C2=NN(C3=C2CN(CC3)S(=O)(C)=O)CCCN4CCC(CC4)N5C6=CC(Cl)=CC=C6N(C5=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ 10329670 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ 10329670400797-24-2JNJ10329670JNJ-10329670Cathepsininvariant chainproteolysisB cellsdendritic cellsantigenT cellInhibitorinhibitorinhibit

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