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  4. JNJ-1289

JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers.

For research use only. We do not sell to patients.

JNJ-1289 Chemical Structure

JNJ-1289 Chemical Structure

CAS No. : 792898-18-1

Size Price Stock Quantity
5 mg USD 625 In-stock
10 mg USD 880 In-stock
25 mg USD 1500 In-stock
50 mg USD 1980 In-stock
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200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

JNJ-1289 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].

IC50 & Target

IC50: 50 nM (hSMOX)[1];
>2 μM (hPAOX and LSD1)[1].
In Vitro

JNJ-1289 (0.1 nM-1 μM, 0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1].
JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-1289 Related Antibodies
Molecular Weight

308.36

Formula

C16H12N4OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C(C=C1)NC2=NC(C3=CN=C4C=CC=CN34)=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (324.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2430 mL 16.2148 mL 32.4296 mL
5 mM 0.6486 mL 3.2430 mL 6.4859 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (8.11 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2430 mL 16.2148 mL 32.4296 mL 81.0741 mL
5 mM 0.6486 mL 3.2430 mL 6.4859 mL 16.2148 mL
10 mM 0.3243 mL 1.6215 mL 3.2430 mL 8.1074 mL
15 mM 0.2162 mL 1.0810 mL 2.1620 mL 5.4049 mL
20 mM 0.1621 mL 0.8107 mL 1.6215 mL 4.0537 mL
25 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
30 mM 0.1081 mL 0.5405 mL 1.0810 mL 2.7025 mL
40 mM 0.0811 mL 0.4054 mL 0.8107 mL 2.0269 mL
50 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
60 mM 0.0540 mL 0.2702 mL 0.5405 mL 1.3512 mL
80 mM 0.0405 mL 0.2027 mL 0.4054 mL 1.0134 mL
100 mM 0.0324 mL 0.1621 mL 0.3243 mL 0.8107 mL
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JNJ-1289 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-1289792898-18-1JNJ1289JNJ 1289OthersSpermine oxidaseHsmoxinflammationcancerpolyamine catabolismInhibitorinhibitorinhibit

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