2. Cytoskeleton
  3. Integrin
  4. JNJ-26076713

JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization.

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JNJ-26076713 Chemical Structure

JNJ-26076713 Chemical Structure

CAS No. : 669076-03-3

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JNJ-26076713 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization[1].

IC50 & Target[1]

αvβ3

2.3 nM (IC50)

αvβ5

6.3 nM (IC50)

In Vitro

JNJ-26076713 (5-5000 nM) inhibits FGF2-induced HUVEC migration in a dose-dependent manner[1].
JNJ-26076713 (0.1, 1, and 10 μg) inhibits angiogenesis in the chick chorioallantoic membrane (CAM) model in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-26076713 Related Antibodies
In Vivo

JNJ-26076713 (30-120 mg/kg; i.g.; twice daily for 5 days; C57BL/6J mice with oxygen-induced retinopathy (OIR) model) inhibits retinal neovascularization in a dose-dependent manner[1].
JNJ-26076713 (60 mg/kg; i.g.; twice daily for 5 days; diabetic Long-Evans rats) inhibits the increase in retinal vascular permeability and leukostasis associated with diabetes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with oxygen-induced retinopathy (OIR) model[1]
Dosage: 30, 60, and 120 mg/kg
Administration: Oral gavage, twice daily for 5 days
Result: Inhibited retinal neovascularization with 33, 43, and 67% inhibition of neovascularization at 30, 60, and 120 mg/kg, respectively.
Animal Model: Diabetic Long-Evans rats[1]
Dosage: 60 mg/kg
Administration: Oral gavage, twice daily for 5 days
Result: Reduced leukocyte adhesion with 48% and inhibited retinal vascular permeability in streptozotocin diabetic rats.
Molecular Weight

490.64

Formula

C29H38N4O3
CAS No.
SMILES

O=C(C[C@@H]([C@H]1CNC2=C(C1)C=CC=C2)CC3CCN(CC3)C(CCC4=CC=C5CCCN=C5N4)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-26076713 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-26076713669076-03-3JNJ26076713JNJ 26076713Integrinretinal neovascularizationretinal vascular permeabilityHUVECFGF2chick chorioallantoic membraneInhibitorinhibitorinhibit

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