2. MAPK/ERK Pathway
  3. JNK
  4. JNK-1-IN-4

JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models.

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JNK-1-IN-4 Chemical Structure

JNK-1-IN-4 Chemical Structure

CAS No. : 3047795-60-5

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JNK-1-IN-4 Related Antibodies

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Description

JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models[1].

IC50 & Target

JNK1

2.7 nM (IC50)

JNK3

9.0 nM (IC50)

JNK2

19.0 nM (IC50)

Molecular Weight

501.38

Formula

C22H25BrN6O3
CAS No.
SMILES

COC1=CC=C(NC2=NC(NC3=CC=C(OCCN(C)C)C=C3C(N)=O)=C(Br)C=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNK-1-IN-4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-1-IN-43047795-60-5JNKc-Jun N-terminal kinaseidiopathic pulmonary fibrosisIPFC57BL/6 mouseanti-fibroticSprague-Dawley ratInhibitorinhibitorinhibit

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