JNK3 inhibitor-2 

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC₅₀ values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition^[1].

JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively^[1].
JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC₅₀s of 0.16, 0.37 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

314.34

C₂₀H₁₄N₂O₂

2366264-18-6

O=C1NC2=C(C=CC=C2)N/C1=C\C(C3=C4C=CC=CC4=CC=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445.  [Content Brief]