2. NF-κB
  3. Keap1-Nrf2
  4. Keap1-Nrf2-IN-13

Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers.

For research use only. We do not sell to patients.

Keap1-Nrf2-IN-13 Chemical Structure

Keap1-Nrf2-IN-13 Chemical Structure

CAS No. : 2456294-92-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Keap1-Nrf2-IN-13 Related Antibodies

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Description

Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers[1].

IC50 & Target

IC50: 0.15 μM (Keap1-Nrf2 PPI)[1]
In Vitro

Keap1-Nrf2-IN-13 (compound 21a, 0.5-50 μM) has inhibitory effect against Keap1-Nrf2 protein–protein interaction (PPI) with an IC50 value of 0.15 μM (fluorescence polarization (FP) assay)[1].
Keap1-Nrf2-IN-13 (0.1 mM, 90 min) has metabolic stability in the presence of human liver microsomes[1].
Keap1-Nrf2-IN-13 forms hydrogen bond interactions with the key polar residues (Asn414, Arg415, Arg483, Gln530), resulting in strong binding affinities to the Keap1 protein (docking assay)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Keap1-Nrf2-IN-13 Related Antibodies
Molecular Weight

620.69

Formula

C28H32N2O10S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N([C@@H](C)C(O)=O)CC1=CC=CC=C1CN([C@@H](C)C(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (483.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6111 mL 8.0556 mL 16.1111 mL
5 mM 0.3222 mL 1.6111 mL 3.2222 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6111 mL 8.0556 mL 16.1111 mL 40.2778 mL
5 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0556 mL
10 mM 0.1611 mL 0.8056 mL 1.6111 mL 4.0278 mL
15 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6852 mL
20 mM 0.0806 mL 0.4028 mL 0.8056 mL 2.0139 mL
25 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6111 mL
30 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
40 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0069 mL
50 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8056 mL
60 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
80 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5035 mL
100 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.4028 mL
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Keap1-Nrf2-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Keap1-Nrf2-IN-132456294-92-9Keap1-Nrf2oxidative stressROShydrogen bondcancerinflammationInhibitorinhibitorinhibit

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