2. Immunology/Inflammation
  3. COX
  4. Ketoprofen (lysinate)

Ketoprofen (lysinate)  (Synonyms: RP-19583 (lysinate))

Cat. No.: HY-B0227A
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Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.

For research use only. We do not sell to patients.

Ketoprofen (lysinate) Chemical Structure

Ketoprofen (lysinate) Chemical Structure

CAS No. : 57469-78-0

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Ketoprofen (lysinate) Related Antibodies

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Description

Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

IC50 & Target

COX-1

2 nM (IC50)

COX-2

26 nM (IC50)

In Vitro

Ketoprofen lysinate inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2)[1].
Ketoprofen lysinate (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ketoprofen (lysinate) Related Antibodies

RT-PCR[3]

Cell Line: LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells
Concentration: 2.5 mg /mL
Incubation Time: 3, 6, 24 h
Result: Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.
In Vivo

Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2].
Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced obese C57BL/6 mice[2]
Dosage: 10 mg/kg
Administration: Oral administration, three times a week for 10 weeks
Result: Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.
Animal Model: LPS (0.2 μg/mL)-treated dairy cows [3]
Dosage: 50 mg/kg
Administration: Injection (Milk samples were taken every 30 min until 6 and 9 h)
Result: Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.
Clinical Trial
Molecular Weight

400.47

Formula

C22H28N2O5
CAS No.
SMILES

N[C@@H](CCCCN)C(O)=O.O=C(O)C(C)C1=CC=CC(C(C2=CC=CC=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ketoprofen (lysinate) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ketoprofen (lysinate)57469-78-0RP-19583 (lysinate)COXCyclooxygenaseAnti-inflammatory agentsCOX inhibitorobesityHFD-induced obese mice3T3-L1 cellwhite adipocytesInhibitorinhibitorinhibit

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