2. Immunology/Inflammation
  3. P-selectin
  4. KF38789

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.

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KF38789 Chemical Structure

KF38789 Chemical Structure

CAS No. : 257292-29-8

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Based on 1 publication(s) in Google Scholar

KF38789 Related Antibodies

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Description

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 GI50
0.25 μM
Compound: 5c
Growth inhibition of human HCT116 cells after 48 hrs
Growth inhibition of human HCT116 cells after 48 hrs
[PMID: 17562361]
HCT-116 EC50
0.56 μM
Compound: 5c
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 17562361]
T47D GI50
0.21 μM
Compound: 5c
Growth inhibition of human T47D cells after 48 hrs
Growth inhibition of human T47D cells after 48 hrs
[PMID: 17562361]
T47D EC50
0.41 μM
Compound: 5c
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 17562361]
In Vitro

KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF38789 significantly inhibits the thioglycollate (TG)-induced accumulation of leukocytes in the mouse peritoneal cavity[1].
KF38789 displays a concentration-dependent inhibition of U937 cell adhesion to immobilized P-selectin-Ig with an IC50 value of 1.97±0.74 μM[1].
KF38789 specifically inhibits P-selectin-dependent cell adhesion and the leukocyte recruitment in mouse peritonitis[1].
KF38789 (5 μM) significantly reduces closure of a 500-μm gap between confluent sheets of Human corneal epithelial (HCE)-T cells over an 8-hr period (by ∼40%)[2].
Corneal epithelial cell migration is reduced in the presence of KF38789 (5 μM) [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KF38789 Related Antibodies
In Vivo

KF38789 can block P-selectin-mediated binding in vitro and leukocyte accumulation in vivo[1].
Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 1 mg/kg
Administration: Intravenously administrated
Result: Significantly reduced leukocyte accumulation.
Animal Model: Twenty-four adult male C57BL/6J (B6) mice, about 6-8 weeks of age and weighing approximately 20-30 g[3]
Dosage: 10 mg/kg, 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg or 0.001 mg/kg
Administration: Intraperitoneal injection daily for 12 days
Result: Significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
Molecular Weight

375.44

Formula

C19H21NO5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OC(C)=CC(O)=C1C2=NCCSC(C2)C3=CC=C(C=C3OC)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (66.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6635 mL 13.3177 mL 26.6354 mL
5 mM 0.5327 mL 2.6635 mL 5.3271 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6635 mL 13.3177 mL 26.6354 mL 66.5885 mL
5 mM 0.5327 mL 2.6635 mL 5.3271 mL 13.3177 mL
10 mM 0.2664 mL 1.3318 mL 2.6635 mL 6.6589 mL
15 mM 0.1776 mL 0.8878 mL 1.7757 mL 4.4392 mL
20 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3294 mL
25 mM 0.1065 mL 0.5327 mL 1.0654 mL 2.6635 mL
30 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2196 mL
40 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6647 mL
50 mM 0.0533 mL 0.2664 mL 0.5327 mL 1.3318 mL
60 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1098 mL
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KF38789 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KF38789257292-29-8KF 38789KF-38789P-selectinCD62P-selectin InhibitorCell adhesionInflammationPSGL-1P-selectin-IgInhibitorinhibitorinhibit

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