2. Cell Cycle/DNA Damage
  3. IRE1
  4. KIRA-7

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.

For research use only. We do not sell to patients.

KIRA-7 Chemical Structure

KIRA-7 Chemical Structure

CAS No. : 1937235-76-1

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5 mg USD 410 In-stock
10 mg USD 670 In-stock
25 mg USD 1340 In-stock
50 mg USD 2150 In-stock
100 mg USD 3500 In-stock
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Based on 1 publication(s) in Google Scholar

KIRA-7 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect[1].

IC50 & Target

IC50: 110 nM (IRE1α kinase)[1]
In Vitro

KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIRA-7 Related Antibodies
In Vivo

KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result: Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased.
Molecular Weight

466.51

Formula

C27H23FN6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC(F)=C1)NC2=C3C=CC=CC3=C(C4=C5C(N)=NC=CN5C(C6(C)CC6)=N4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1436 mL 10.7179 mL 21.4358 mL
5 mM 0.4287 mL 2.1436 mL 4.2872 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1436 mL 10.7179 mL 21.4358 mL 53.5894 mL
5 mM 0.4287 mL 2.1436 mL 4.2872 mL 10.7179 mL
10 mM 0.2144 mL 1.0718 mL 2.1436 mL 5.3589 mL
15 mM 0.1429 mL 0.7145 mL 1.4291 mL 3.5726 mL
20 mM 0.1072 mL 0.5359 mL 1.0718 mL 2.6795 mL
25 mM 0.0857 mL 0.4287 mL 0.8574 mL 2.1436 mL
30 mM 0.0715 mL 0.3573 mL 0.7145 mL 1.7863 mL
40 mM 0.0536 mL 0.2679 mL 0.5359 mL 1.3397 mL
50 mM 0.0429 mL 0.2144 mL 0.4287 mL 1.0718 mL
60 mM 0.0357 mL 0.1786 mL 0.3573 mL 0.8932 mL
80 mM 0.0268 mL 0.1340 mL 0.2679 mL 0.6699 mL
100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5359 mL
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KIRA-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIRA-71937235-76-1KIRA7KIRA 7IRE1Inositol requiring enzyme 1IRE1αfibrosisXBP1 ATF4BiPCHOPcollagen-1A1fibronectinER stressInhibitorinhibitorinhibit

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