2. GPCR/G Protein
  3. GnRH Receptor
  4. Kisspeptin 13

Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.

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Kisspeptin 13 Chemical Structure

Kisspeptin 13 Chemical Structure

CAS No. : 374675-18-0

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Kisspeptin 13 Related Antibodies

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Description

Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
22.8 nM
Compound: 13-mer, metastin-13
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
[PMID: 17266198]
HEK293 EC50
33 nM
Compound: Y4A
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
[PMID: 17266198]
In Vivo

Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice with memory impairment induced by A-beta[1]
Dosage: 2 μg/side
Administration: Intracerebroventricular administration; 2 μg/side; once
Result: Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.
Molecular Weight

1626.81

Formula

C78H107N21O18
CAS No.
Sequence

Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence Shortening

LPNYNWNSFGLRF-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Kisspeptin 13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kisspeptin 13374675-18-0Kisspeptin13Kisspeptin-13GnRH ReceptorGonadotropin releasing hormone receptorGNRHRSprague-Dawley ratpertussis toxinhyperthermiaanxietyantidepressantAlzheimer's diseaseswiss mouseInhibitorinhibitorinhibit

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