2. PROTAC
  3. PROTACs
  4. KL-465

KL-465 is a PROTAC degrader for MAGE-A3, that degrades MAGE-A3 with a DC50 of 2 μM in HeLa cell. KL-465 inhibits viability of MAGE-A3 positive cancer cell HCT116, A375 and HeLa. (Blue: Ligand for E3 ligase (HY-151227); Black: Linker (HY-W679862); Pink: Ligand for target protein (HY-169087))

For research use only. We do not sell to patients.

KL-465 Chemical Structure

KL-465 Chemical Structure

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KL-465 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

KL-465 is a PROTAC degrader for MAGE-A3, that degrades MAGE-A3 with a DC50 of 2 μM in HeLa cell. KL-465 inhibits viability of MAGE-A3 positive cancer cell HCT116, A375 and HeLa. (Blue: Ligand for E3 ligase (HY-151227); Black: Linker (HY-W679862); Pink: Ligand for target protein (HY-169087))[1]

Molecular Weight

1021.19

Formula

C56H60N8O9S
SMILES

O=C(N1CCN(CC2=CC(C3=CC=CC4=C3C=NN4)=CC=C2OCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([C@H]7N(C([C@@H](N(CC8=C9C=CC=C8)C9=O)C(C)C)=O)C[C@H](O)C7)=O)CC1)C%10=CC=CO%10
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KL-465 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KL-465KL465KL 465PROTACsHCT116A375HeLaMOLM13HEK293Inhibitorinhibitorinhibit

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HY-169086
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