2. PROTAC
  3. Ligands for E3 Ligase
  4. VL285 Phenol

VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).

For research use only. We do not sell to patients.

VL285 Phenol Chemical Structure

VL285 Phenol Chemical Structure

CAS No. : 1448188-69-9

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Customer Review

Based on 1 publication(s) in Google Scholar

VL285 Phenol Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).

In Vitro

VL285 (100 μM; 24 h) attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VL285 Phenol Related Antibodies
Molecular Weight

548.65

Formula

C29H32N4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N=CS1)=C1C2=CC(O)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8227 mL 9.1133 mL 18.2266 mL
5 mM 0.3645 mL 1.8227 mL 3.6453 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8227 mL 9.1133 mL 18.2266 mL 45.5664 mL
5 mM 0.3645 mL 1.8227 mL 3.6453 mL 9.1133 mL
10 mM 0.1823 mL 0.9113 mL 1.8227 mL 4.5566 mL
15 mM 0.1215 mL 0.6076 mL 1.2151 mL 3.0378 mL
20 mM 0.0911 mL 0.4557 mL 0.9113 mL 2.2783 mL
25 mM 0.0729 mL 0.3645 mL 0.7291 mL 1.8227 mL
30 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5189 mL
40 mM 0.0456 mL 0.2278 mL 0.4557 mL 1.1392 mL
50 mM 0.0365 mL 0.1823 mL 0.3645 mL 0.9113 mL
60 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7594 mL
80 mM 0.0228 mL 0.1139 mL 0.2278 mL 0.5696 mL
100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4557 mL
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VL285 Phenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VL285 Phenol1448188-69-9Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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VL285 Phenol
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HY-151227
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