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  4. KLF10-IN-1

KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25−T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology.

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KLF10-IN-1 Chemical Structure

KLF10-IN-1 Chemical Structure

CAS No. : 1197834-98-2

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Based on 1 publication(s) in Google Scholar

KLF10-IN-1 Related Antibodies

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Description

KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25−T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology[1].

IC50 & Target

Krüppel-Like Factor 10 (KLF10)[1].
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
40 μM
Compound: 48-15
Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay
Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay
[PMID: 25581017]
Molecular Weight

300.31

Formula

C17H16O5
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(OCC(C1=CC=C(OC)C=C1)=O)C2=CC(C)=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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KLF10-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLF10-IN-11197834-98-2OthersT regulatory cell differentiationCD4+CD25? T cellsCD4+CD25+ T regulatory cellsInhibitorinhibitorinhibit

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