2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. KOTX1

KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models.

For research use only. We do not sell to patients.

KOTX1 Chemical Structure

KOTX1 Chemical Structure

CAS No. : 1788963-83-6

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Based on 1 publication(s) in Google Scholar

KOTX1 Related Antibodies

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ALDH1 ALDH2 ALDH3

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Description

KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models[1].

IC50 & Target[1]

ALDH1A3

 

In Vitro

KOTX1 (0-1 μM) has an IC50 of 5.14 nM for ALDH1A3 in A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KOTX1 Related Antibodies
In Vivo

KOTX1 (40 mg/kg; oral gavage; 4 weeks) has an improved effect in diabetic mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male db/db mice aged 5 months old[1]
Dosage: 40 mg/kg
Administration: Oral gavage (i.g.); 4 weeks
Result: Improved glucose tolerance in mice.
Increased plasma insulin levels.
Did not change body weight and food intake.
Molecular Weight

313.33

Formula

C17H16FN3O2
CAS No.
SMILES

O=C(C1=C(CC)C=NC=C1)NC2=C(F)C=C(NC(CC3)=O)C3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (398.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1915 mL 15.9576 mL 31.9152 mL
5 mM 0.6383 mL 3.1915 mL 6.3830 mL
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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1915 mL 15.9576 mL 31.9152 mL 79.7881 mL
5 mM 0.6383 mL 3.1915 mL 6.3830 mL 15.9576 mL
10 mM 0.3192 mL 1.5958 mL 3.1915 mL 7.9788 mL
15 mM 0.2128 mL 1.0638 mL 2.1277 mL 5.3192 mL
20 mM 0.1596 mL 0.7979 mL 1.5958 mL 3.9894 mL
25 mM 0.1277 mL 0.6383 mL 1.2766 mL 3.1915 mL
30 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6596 mL
40 mM 0.0798 mL 0.3989 mL 0.7979 mL 1.9947 mL
50 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5958 mL
60 mM 0.0532 mL 0.2660 mL 0.5319 mL 1.3298 mL
80 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9974 mL
100 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7979 mL
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KOTX1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KOTX11788963-83-6KOTX 1KOTX-1Aldehyde Dehydrogenase (ALDH)A375 cellsdiabetic modelInhibitorinhibitorinhibit

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