KRAS G12C inhibitor 15

Cat. No.: HY-125873 Purity: 98.47%: FAQs
Data Sheet SDS COA Handling Instructions

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KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC₅₀ of 5 nM.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 15 Chemical Structure

CAS No. : 2349393-21-9

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 920	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5000	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC₅₀ of 5 nM^[1].

IC₅₀ & Target^[1]

KRas G12C

5 nM (IC₅₀)

Molecular Weight

498.91

Formula

C₂₅H₂₁ClF₂N₄O₃

CAS No.

2349393-21-9

Appearance

Solid

Color

White to yellow

SMILES

FC1=C(N=CC(N2C)=C3N4[C@H](CN(C(C=C)=O)[C@H](C)C4)C2=O)C3=CC(Cl)=[C@@]1[C@@]5=C(F)C=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 193.33 mg/mL (387.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0044 mL	10.0218 mL	20.0437 mL
5 mM	0.4009 mL	2.0044 mL	4.0087 mL
10 mM	0.2004 mL	1.0022 mL	2.0044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.47%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (257 KB) RP-HPLC (257 KB)

Handling Instructions (2659 KB)

References

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0044 mL	10.0218 mL	20.0437 mL	50.1092 mL
	5 mM	0.4009 mL	2.0044 mL	4.0087 mL	10.0218 mL
	10 mM	0.2004 mL	1.0022 mL	2.0044 mL	5.0109 mL
	15 mM	0.1336 mL	0.6681 mL	1.3362 mL	3.3406 mL
	20 mM	0.1002 mL	0.5011 mL	1.0022 mL	2.5055 mL
	25 mM	0.0802 mL	0.4009 mL	0.8017 mL	2.0044 mL
	30 mM	0.0668 mL	0.3341 mL	0.6681 mL	1.6703 mL
	40 mM	0.0501 mL	0.2505 mL	0.5011 mL	1.2527 mL
	50 mM	0.0401 mL	0.2004 mL	0.4009 mL	1.0022 mL
	60 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL
	80 mM	0.0251 mL	0.1253 mL	0.2505 mL	0.6264 mL
	100 mM	0.0200 mL	0.1002 mL	0.2004 mL	0.5011 mL