KRC-00715 

KRC-00715 is an effective oral c-Met inhibitor with an IC₅₀ of 9.0 nM, demonstrating high selectivity in gastric cancer cells. KRC-00715 specifically inhibits the growth of c-Met-highly expressed cell lines by inducing G1/S phase arrest, leading to a reduction in downstream signaling pathways, including Akt and Erk, as well as c-Met activity. KRC-00715, in the gastric cancer cell line Hs746, is characterized by an IC₅₀ of 39 nM, and it selectively inhibits the proliferation of c-Met-highly expressed cell lines. KRC-00715 reduces tumor size in Hs746T xenograft mouse models^[1].

KRC-00715 exhibits a cytotoxic IC₅₀ of 39 nM, demonstrating its efficacy as a potent c-Met inhibitor^[1].
KRC-00715 (8, 40, 200, 1000 nM; 3 h; Hs746T, AGS) inhibits the autophosphorylation of c-Met, indicating that the suppression of c-Met activity significantly contributes to the inhibition of Hs746T cell proliferation^[1].
KRC-00715 plays a role in c-Met high-expression cell lines and has an IC₅₀ value of 39 nM in HS746T cells, and inhibits c-Met autophosphorylation in high-expression cell lines; phosphorylation of AKT and ERK^[1].
KRC-00715 (30 nM and 300 nM) blocked SNU-5 G1/S more than SNU-1, with numerical values of 72.53 and 64.54 at 30 nM, respectively, at 300 nM, the values are 73.62 and 83.64 respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRC-00715 (50 mg/kg; p.o.; once daily; 10 days) inhibited tumor volume increased in a nude mouse xenograft HS746T model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

542.51

C₂₅H₂₅F₃N₈O₃

2079853-72-6

FC(F)(F)C1=C(OCCN2CCOCC2)C=CC(C3=NC(N(CC4OC(C=CC=N5)=C5NC4)N=N6)=C6N=C3)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chi Hoon Park, et al. Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells.BMC Cancer. 2016 Jan 22:16:35.  [Content Brief]