KS100

Name: KS100
Brand: MedChemExpress
SKU: HY-146682
Rating: 4.5 (1 reviews)

Cat. No.: HY-146682 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

KS100 is a potent ALDH inhibitor with IC₅₀s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.

For research use only. We do not sell to patients.

KS100 Chemical Structure

CAS No. : 2408477-54-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

View All Isoforms

ALDH1 ALDH2 ALDH3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC₅₀: 230 nM (ALDH1A1); 1542 nM (ALDH2); 193 nM (ALDH3A1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	2.9 μM Compound: 3j; KS100	Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
HT-29	IC₅₀	2.5 μM Compound: 3j; KS100	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
MM1.S	IC₅₀	2.1 μM Compound: 3j; KS100	Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay	[PMID: 31887569]
NCI-H929	IC₅₀	0.3 μM Compound: 3j; KS100	Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
RPMI-8226	IC₅₀	1.2 μM Compound: 3j; KS100	Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
U-266	IC₅₀	1 μM Compound: 3j; KS100	Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
UACC-903	IC₅₀	3.7 μM Compound: 3j; KS100	Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay	[PMID: 31887569]

In Vitro

KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC₅₀s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively^[1].
KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HCT116, HT29 cells
Concentration:	5 µM
Incubation Time:	24 h
Result:	Induced cell apoptosis.

Apoptosis Analysis^[1]

Cell Line:	HCT116 cells
Concentration:	5 µM
Incubation Time:	24 h
Result:	Induced cell cycle arrest at G2/M phase.

Molecular Weight

564.09

Formula

C₁₇H₁₄Br₃N₃O₂S

CAS No.

2408477-54-1

Appearance

Solid

Color

Yellow to orange

SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(Br)=CC(Br)=C32)=O)=O)N.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (221.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7728 mL	8.8638 mL	17.7277 mL
5 mM	0.3546 mL	1.7728 mL	3.5455 mL
10 mM	0.1773 mL	0.8864 mL	1.7728 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (250 KB) HNMR (286 KB) RP-HPLC (249 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7728 mL	8.8638 mL	17.7277 mL	44.3192 mL
	5 mM	0.3546 mL	1.7728 mL	3.5455 mL	8.8638 mL
	10 mM	0.1773 mL	0.8864 mL	1.7728 mL	4.4319 mL
	15 mM	0.1182 mL	0.5909 mL	1.1818 mL	2.9546 mL
	20 mM	0.0886 mL	0.4432 mL	0.8864 mL	2.2160 mL
	25 mM	0.0709 mL	0.3546 mL	0.7091 mL	1.7728 mL
	30 mM	0.0591 mL	0.2955 mL	0.5909 mL	1.4773 mL
	40 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1080 mL
	50 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	60 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL
	80 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5540 mL
	100 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL

KS100 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS1002408477-54-1KS 100KS-100Aldehyde Dehydrogenase (ALDH)Apoptosislow toxicantiproliferativeanticancerROS activitylipid peroxidationtoxic aldehyde accumulationapoptosisG2/M phaseHCT116 cellsInhibitorinhibitorinhibit

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KS100

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KS100 Related Antibodies

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View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

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References

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KS100 Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

KS100 Related Classifications

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