2. Metabolic Enzyme/Protease Apoptosis
  3. Aldehyde Dehydrogenase (ALDH) Apoptosis
  4. KS100

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.

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KS100 Chemical Structure

KS100 Chemical Structure

CAS No. : 2408477-54-1

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Based on 1 publication(s) in Google Scholar

KS100 Related Antibodies

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View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

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ALDH1 ALDH2 ALDH3

  • Biological Activity

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Description

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase[1].

IC50 & Target

IC50: 230 nM (ALDH1A1); 1542 nM (ALDH2); 193 nM (ALDH3A1)[1]
In Vitro

KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1].
KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KS100 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HCT116, HT29 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G2/M phase.
Molecular Weight

564.09

Formula

C17H14Br3N3O2S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(Br)=CC(Br)=C32)=O)=O)N.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (221.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7728 mL 8.8638 mL 17.7277 mL
5 mM 0.3546 mL 1.7728 mL 3.5455 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7728 mL 8.8638 mL 17.7277 mL 44.3192 mL
5 mM 0.3546 mL 1.7728 mL 3.5455 mL 8.8638 mL
10 mM 0.1773 mL 0.8864 mL 1.7728 mL 4.4319 mL
15 mM 0.1182 mL 0.5909 mL 1.1818 mL 2.9546 mL
20 mM 0.0886 mL 0.4432 mL 0.8864 mL 2.2160 mL
25 mM 0.0709 mL 0.3546 mL 0.7091 mL 1.7728 mL
30 mM 0.0591 mL 0.2955 mL 0.5909 mL 1.4773 mL
40 mM 0.0443 mL 0.2216 mL 0.4432 mL 1.1080 mL
50 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8864 mL
60 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.7387 mL
80 mM 0.0222 mL 0.1108 mL 0.2216 mL 0.5540 mL
100 mM 0.0177 mL 0.0886 mL 0.1773 mL 0.4432 mL
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KS100 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS1002408477-54-1KS 100KS-100Aldehyde Dehydrogenase (ALDH)Apoptosislow toxicantiproliferativeanticancerROS activitylipid peroxidationtoxic aldehyde accumulationapoptosisG2/M phaseHCT116 cellsInhibitorinhibitorinhibit

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