2. Immunology/Inflammation
  3. Complement System
  4. L-156602

L-156602  (Synonyms: Antibiotic L 156602; PD 124966)

Cat. No.: HY-16384
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L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH).

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L-156602 Chemical Structure

L-156602 Chemical Structure

CAS No. : 125228-51-5

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Description

L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].

IC50 & Target

C5a receptor[1][2]
In Vivo

L-156602 (0.1-0.5 mg/kg, i.p., once daily for 3 days) suppressed inflammation significantly in CDF1 mice induced by Concanavalin A (HY-P2149) and BALB/c mice induced by Muramyl dipeptide (MDP) (HY-127090)[1][2].
L-156602 (0.2-0.5 mg/kg, i.p.) suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation in PCI-induced inflammation of DBA/1 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Concanavalin A-induced inflammation of CDF1 mice[1][2]
Dosage: 0.1, 0.5 mg/kg, once daily for 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed the swelling completely after 4 h at 0.1 mg/kg, and the effect was still statistical after 24 h at 0.5 mg/kg.
Reduced the number of migrated leukocytes.
Suppressed the migration of neutrophils, macrophages and lymphocytes non-specifically.
Animal Model: MDP-induced acute joint inflammation of BALB/c mice[1]
Dosage: 0.25, 0.5 mg/kg, once daily for 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed adjuvant arthritis although a slight reduction of body weight at the dose of 0.5 mg/kg after 24 h.
Animal Model: 0.5% PCI-induced inflammation of DBA/1 mice[2]
Dosage: 0.2, 0.5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed ear swelling significantly and the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation.
Animal Model: 5% PCI-induced inflammation of DBA/1 mice[2]
Dosage: 0.4 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation non-specifically.
Molecular Weight

840.96

Formula

C38H64N8O13
CAS No.
SMILES

CC[C@@H](C[C@H]1CC[C@@]([C@@](C(N[C@H]2[C@H](C(C)C)OC([C@@H](C)N(O)C([C@H]3CCCNN3C(CNC([C@H](C)N(O)C([C@@H]4CCCNN4C2=O)=O)=O)=O)=O)=O)=O)(O)C)(O)O[C@@H]1C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-156602 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-156602125228-51-5Antibiotic L 156602 PD 124966L156602L 156602Antibiotic L156602Antibiotic L-156602PD124966PD 124966PD-124966Complement Systemconcanavalin AMDP or PCI induced mouse modelsinflammationdelayed-type hypersensitivity (DTH)Inhibitorinhibitorinhibit

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