1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-5-Hydroxytryptophan-d3

L-5-Hydroxytryptophan-d3  (Synonyms: L-5-HTP-d3; Oxitriptan-d3)

Cat. No.: HY-B1716S Purity: 99.35%
COA Handling Instructions

L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].

For research use only. We do not sell to patients.

L-5-Hydroxytryptophan-d<sub>3</sub> Chemical Structure

L-5-Hydroxytryptophan-d3 Chemical Structure

CAS No. : 1276197-29-5

Size Price Stock Quantity
1 mg USD 150 In-stock
5 mg USD 450 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.24

Formula

C11H9D3N2O3

CAS No.
Unlabeled CAS

4350-09-8

Appearance

Solid

Color

Gray to dark gray

SMILES

OC([C@@H](N)CC(C1=C2[2H])=CNC1=C([2H])C([2H])=C2O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (55.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 12.5 mg/mL (55.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4795 mL 22.3974 mL 44.7948 mL
5 mM 0.8959 mL 4.4795 mL 8.9590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.35%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 4.4795 mL 22.3974 mL 44.7948 mL 111.9871 mL
5 mM 0.8959 mL 4.4795 mL 8.9590 mL 22.3974 mL
10 mM 0.4479 mL 2.2397 mL 4.4795 mL 11.1987 mL
15 mM 0.2986 mL 1.4932 mL 2.9863 mL 7.4658 mL
20 mM 0.2240 mL 1.1199 mL 2.2397 mL 5.5994 mL
25 mM 0.1792 mL 0.8959 mL 1.7918 mL 4.4795 mL
30 mM 0.1493 mL 0.7466 mL 1.4932 mL 3.7329 mL
40 mM 0.1120 mL 0.5599 mL 1.1199 mL 2.7997 mL
50 mM 0.0896 mL 0.4479 mL 0.8959 mL 2.2397 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
L-5-Hydroxytryptophan-d3
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