L-5-Hydroxytryptophan-d₃ (Synonyms: L-5-HTP-d₃; Oxitriptan-d₃)

Name: L-5-Hydroxytryptophan-d 3
Brand: MedChemExpress
SKU: HY-B1716S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1716S Purity: 99.35%: FAQs
Data Sheet SDS COA Handling Instructions

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L-5-Hydroxytryptophan-d₃ is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].

For research use only. We do not sell to patients.

L-5-Hydroxytryptophan-d<sub>3</sub> Chemical Structure

L-5-Hydroxytryptophan-d₃ Chemical Structure

CAS No. : 1276197-29-5

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 450	Get quote	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.24

Formula

C₁₁H₉D₃N₂O₃

CAS No.

1276197-29-5

Unlabeled CAS

4350-09-8

Appearance

Solid

Color

Gray to dark gray

SMILES

OC([C@@H](N)CC(C1=C2[2H])=CNC1=C([2H])C([2H])=C2O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (55.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4795 mL	22.3974 mL	44.7948 mL
5 mM	0.8959 mL	4.4795 mL	8.9590 mL
10 mM	0.4479 mL	2.2397 mL	4.4795 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.35%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (252 KB) HNMR (902 KB) RP-HPLC (316 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. ARVID CARLSSON, et al. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, page1200 (1957).

[3]. Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990 May-Jun;18(3):201-9. [Content Brief]

[4]. Thal LJ, et al. Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations. Ann Neurol. 1980 Jun;7(6):570-6. [Content Brief]

[5]. Boiardi A, et al. 5-OH-Tryptophane in migraine: clinical and neurophysiological considerations. J Neurol. 1981;225(1):41-6. [Content Brief]

[6]. Trouillas P, et al. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantified data processing. Arch Neurol. 1988 Nov;45(11):1217-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	4.4795 mL	22.3974 mL	44.7948 mL	111.9871 mL
	5 mM	0.8959 mL	4.4795 mL	8.9590 mL	22.3974 mL
	10 mM	0.4479 mL	2.2397 mL	4.4795 mL	11.1987 mL
	15 mM	0.2986 mL	1.4932 mL	2.9863 mL	7.4658 mL
	20 mM	0.2240 mL	1.1199 mL	2.2397 mL	5.5994 mL
	25 mM	0.1792 mL	0.8959 mL	1.7918 mL	4.4795 mL
	30 mM	0.1493 mL	0.7466 mL	1.4932 mL	3.7329 mL
	40 mM	0.1120 mL	0.5599 mL	1.1199 mL	2.7997 mL
	50 mM	0.0896 mL	0.4479 mL	0.8959 mL	2.2397 mL

L-5-Hydroxytryptophan-d₃ Related Classifications

Neurological Disease Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-5-Hydroxytryptophan-d₃1276197-29-5L-5-HTP-d₃Oxitriptan-d₃Endogenous MetaboliteInhibitorinhibitorinhibit

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L-5-Hydroxytryptophan-d3 (Synonyms: L-5-HTP-d3; Oxitriptan-d3)

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L-5-Hydroxytryptophan-d₃ (Synonyms: L-5-HTP-d₃; Oxitriptan-d₃)

Other Forms of L-5-Hydroxytryptophan-d₃:

L-5-Hydroxytryptophan-d₃ Related Antibodies

L-5-Hydroxytryptophan-d₃ Related Antibodies

L-5-Hydroxytryptophan-d₃ Related Classifications