2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic DNA/RNA Synthesis
  4. L-Alanosine

L-Alanosine  (Synonyms: NSC-153353; SDX-102)

Cat. No.: HY-16933 Purity: ≥99.0%
SDS
COA
Handling Instructions Technical Support

L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP).

For research use only. We do not sell to patients.

L-Alanosine Chemical Structure

L-Alanosine Chemical Structure

CAS No. : 5854-93-3

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Based on 1 publication(s) in Google Scholar

L-Alanosine Related Antibodies

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1 Publications Citing Use of MCE L-Alanosine

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Description

L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP)[1][2][3].

In Vitro

L-Alanosine (0.1-100 μM, 10 days) blocks the de novo purine synthesis pathway by inhibiting the activity of adenylosuccinate synthetase (ADSS), thereby inhibiting the proliferation of MTAP-deficient tumor cells CEM/ADR5000, HL-60/AR and MDA-MB-231-BCRP because these cells cannot obtain adenine through the salvage pathway[1].
L-Alanosine (0.125-0.25 μM, 14 days) inhibits the mitochondrial function (especially mitochondrial spare respiratory capacity), reduces the stemness of GBM cells, increases a synergistic inhibitory effect with Temozolomide (HY-17364)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Alanosine Related Antibodies

Cell Proliferation Assay[1]

Cell Line: CEM/ADR5000, HL-60/AR, MDA-MB-231-BCRP
Concentration: 0.1-100 μM
Incubation Time: 10 days
Result: Inhibited cell growth.
In Vivo

L-Alanosine (150 mg/kg, ip, three times a week for 7 weeks) exhibits antitumor activity with the combination of Temozolomide (HY-17364) in GBM 12-0160 xenograft mouse models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GBM 12-0160 xenograft mouse models[4]
Dosage: 150 mg/kg
Administration: ip, three times a week for 7 weeks
Result: Inhibited tumor growth, prolonged the survival rate.
Molecular Weight

149.11

Formula

C3H7N3O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@@H](CN(O)N=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (335.32 mM; Need ultrasonic)

H2O : 15 mg/mL (100.60 mM; ultrasonic and adjust pH to 8 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7065 mL 33.5323 mL 67.0646 mL
5 mM 1.3413 mL 6.7065 mL 13.4129 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (392 KB)

COA (246 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 6.7065 mL 33.5323 mL 67.0646 mL 167.6615 mL
5 mM 1.3413 mL 6.7065 mL 13.4129 mL 33.5323 mL
10 mM 0.6706 mL 3.3532 mL 6.7065 mL 16.7661 mL
15 mM 0.4471 mL 2.2355 mL 4.4710 mL 11.1774 mL
20 mM 0.3353 mL 1.6766 mL 3.3532 mL 8.3831 mL
25 mM 0.2683 mL 1.3413 mL 2.6826 mL 6.7065 mL
30 mM 0.2235 mL 1.1177 mL 2.2355 mL 5.5887 mL
40 mM 0.1677 mL 0.8383 mL 1.6766 mL 4.1915 mL
50 mM 0.1341 mL 0.6706 mL 1.3413 mL 3.3532 mL
60 mM 0.1118 mL 0.5589 mL 1.1177 mL 2.7944 mL
80 mM 0.0838 mL 0.4192 mL 0.8383 mL 2.0958 mL
100 mM 0.0671 mL 0.3353 mL 0.6706 mL 1.6766 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Alanosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Alanosine5854-93-3NSC-153353 SDX-102NSC153353NSC 153353SDX102SDX 102SDX-102AntibioticDNA/RNA SynthesisInhibitorinhibitorinhibit

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