2. Anti-infection
  3. Antibiotic
  4. L-Alanosine

L-Alanosine  (Synonyms: NSC-153353; SDX-102)

Cat. No.: HY-16933 Purity: ≥99.0%
COA Handling Instructions

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L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency.

For research use only. We do not sell to patients.

L-Alanosine Chemical Structure

L-Alanosine Chemical Structure

CAS No. : 5854-93-3

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1 mg USD 150 In-stock
5 mg USD 440 In-stock
10 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

L-Alanosine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L-Alanosine

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Description

L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency[1][2][3].

Molecular Weight

149.11

Formula

C3H7N3O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@@H](CN(O)N=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (335.32 mM; Need ultrasonic)

H2O : 15 mg/mL (100.60 mM; ultrasonic and adjust pH to 8 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7065 mL 33.5323 mL 67.0646 mL
5 mM 1.3413 mL 6.7065 mL 13.4129 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

Animal weight
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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (246 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 6.7065 mL 33.5323 mL 67.0646 mL 167.6615 mL
5 mM 1.3413 mL 6.7065 mL 13.4129 mL 33.5323 mL
10 mM 0.6706 mL 3.3532 mL 6.7065 mL 16.7661 mL
15 mM 0.4471 mL 2.2355 mL 4.4710 mL 11.1774 mL
20 mM 0.3353 mL 1.6766 mL 3.3532 mL 8.3831 mL
25 mM 0.2683 mL 1.3413 mL 2.6826 mL 6.7065 mL
30 mM 0.2235 mL 1.1177 mL 2.2355 mL 5.5887 mL
40 mM 0.1677 mL 0.8383 mL 1.6766 mL 4.1915 mL
50 mM 0.1341 mL 0.6706 mL 1.3413 mL 3.3532 mL
60 mM 0.1118 mL 0.5589 mL 1.1177 mL 2.7944 mL
80 mM 0.0838 mL 0.4192 mL 0.8383 mL 2.0958 mL
100 mM 0.0671 mL 0.3353 mL 0.6706 mL 1.6766 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Alanosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Alanosine5854-93-3NSC-153353 SDX-102NSC153353NSC 153353SDX102SDX 102SDX-102AntibioticInhibitorinhibitorinhibit

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