2. Others NF-κB Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
  4. L-Ascorbic acid-13C6

L-Ascorbic acid-13C6  (Synonyms: L-Ascorbate-13C6; Vitamin C-13C6)

Cat. No.: HY-B0166S Purity: 99.65%
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L-Ascorbic acid-13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

For research use only. We do not sell to patients.

L-Ascorbic acid-<sup>13</sup>C<sub>6</sub> Chemical Structure

L-Ascorbic acid-13C6 Chemical Structure

CAS No. : 1354064-87-1

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid-13C6:

L-Ascorbic acid-13C6 Related Antibodies

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Description

L-Ascorbic acid-13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid-13C6 Related Antibodies
Molecular Weight

182.08

Formula

13C6H8O6
CAS No.
Unlabeled CAS

50-81-7
Appearance

Solid

Color

White to off-white

SMILES

O[13CH2][13C@@H]([13C@]1([H])[13C](O)=[13C]([13C](O1)=O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (549.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4921 mL 27.4605 mL 54.9209 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4921 mL 27.4605 mL 54.9209 mL 137.3023 mL
5 mM 1.0984 mL 5.4921 mL 10.9842 mL 27.4605 mL
10 mM 0.5492 mL 2.7460 mL 5.4921 mL 13.7302 mL
15 mM 0.3661 mL 1.8307 mL 3.6614 mL 9.1535 mL
20 mM 0.2746 mL 1.3730 mL 2.7460 mL 6.8651 mL
25 mM 0.2197 mL 1.0984 mL 2.1968 mL 5.4921 mL
30 mM 0.1831 mL 0.9153 mL 1.8307 mL 4.5767 mL
40 mM 0.1373 mL 0.6865 mL 1.3730 mL 3.4326 mL
50 mM 0.1098 mL 0.5492 mL 1.0984 mL 2.7460 mL
60 mM 0.0915 mL 0.4577 mL 0.9153 mL 2.2884 mL
80 mM 0.0687 mL 0.3433 mL 0.6865 mL 1.7163 mL
100 mM 0.0549 mL 0.2746 mL 0.5492 mL 1.3730 mL
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L-Ascorbic acid-13C6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid-13C61354064-87-1L-Ascorbate-13C6Vitamin C-13C6Isotope-Labeled CompoundsReactive Oxygen SpeciesCalcium ChannelApoptosisEndogenous MetaboliteCa2+ channelsCa channelsInhibitorinhibitorinhibit

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