L-Ascorbic acid-¹³C₆ (Synonyms: L-Ascorbate-¹³C₆; Vitamin C-¹³C₆)

Cat. No.: HY-B0166S: FAQs
Data Sheet Handling Instructions

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L-Ascorbic acid-¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

For research use only. We do not sell to patients.

L-Ascorbic acid-<sup>13</sup>C<sub>6</sub> Chemical Structure

L-Ascorbic acid-¹³C₆ Chemical Structure

CAS No. : 1354064-87-1

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of L-Ascorbic acid-¹³C₆:

L-Ascorbic acid In-stock

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

182.08

Formula

¹³C₆H₈O₆

CAS No.

1354064-87-1

Unlabeled CAS

50-81-7

SMILES

O[13CH2][13C@@H]([13C@]1([H])[13C](O)=[13C]([13C](O1)=O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (549.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4921 mL	27.4605 mL	54.9209 mL
5 mM	1.0984 mL	5.4921 mL	10.9842 mL
10 mM	0.5492 mL	2.7460 mL	5.4921 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35. [Content Brief]

[3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [Content Brief]

[4]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]

[5]. Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372. [Content Brief]

[6]. Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.4921 mL	27.4605 mL	54.9209 mL	137.3023 mL
	5 mM	1.0984 mL	5.4921 mL	10.9842 mL	27.4605 mL
	10 mM	0.5492 mL	2.7460 mL	5.4921 mL	13.7302 mL
	15 mM	0.3661 mL	1.8307 mL	3.6614 mL	9.1535 mL
	20 mM	0.2746 mL	1.3730 mL	2.7460 mL	6.8651 mL
	25 mM	0.2197 mL	1.0984 mL	2.1968 mL	5.4921 mL
	30 mM	0.1831 mL	0.9153 mL	1.8307 mL	4.5767 mL
	40 mM	0.1373 mL	0.6865 mL	1.3730 mL	3.4326 mL
	50 mM	0.1098 mL	0.5492 mL	1.0984 mL	2.7460 mL
	60 mM	0.0915 mL	0.4577 mL	0.9153 mL	2.2884 mL
	80 mM	0.0687 mL	0.3433 mL	0.6865 mL	1.7163 mL
	100 mM	0.0549 mL	0.2746 mL	0.5492 mL	1.3730 mL

L-Ascorbic acid-¹³C₆ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid-¹³C₆1354064-87-1L-Ascorbate-¹³C₆Vitamin C-¹³C₆Isotope-Labeled CompoundsReactive Oxygen SpeciesCalcium ChannelApoptosisEndogenous MetaboliteCa2+ channelsCa channelsInhibitorinhibitorinhibit

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L-Ascorbic acid-13C6 (Synonyms: L-Ascorbate-13C6; Vitamin C-13C6)

Other Forms of L-Ascorbic acid-13C6:

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