2. Neuronal Signaling GPCR/G Protein Metabolic Enzyme/Protease
  3. Dopamine Receptor Endogenous Metabolite
  4. L-DOPA-2,5,6-d3

L-DOPA-2,5,6-d3 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain[1][2][3].

For research use only. We do not sell to patients.

L-DOPA-2,5,6-d<sub>3</sub> Chemical Structure

L-DOPA-2,5,6-d3 Chemical Structure

CAS No. : 53587-29-4

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50 mg USD 160 In-stock
100 mg USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-DOPA-2,5,6-d3:

L-DOPA-2,5,6-d3 Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

L-DOPA-2,5,6-d3 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain[1][2][3].

IC50 & Target

D3 Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-DOPA-2,5,6-d3 Related Antibodies
Molecular Weight

200.21

Formula

C9H8D3NO4
CAS No.
Unlabeled CAS

59-92-7
Appearance

Solid

Color

Off-white to light yellow

SMILES

C([C@@H](C(O)=O)N)C1=C(C(O)=C(O)C(=C1[2H])[2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (124.87 mM; ultrasonic and warming and adjust pH to 1 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9948 mL 24.9738 mL 49.9476 mL
5 mM 0.9990 mL 4.9948 mL 9.9895 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9948 mL 24.9738 mL 49.9476 mL 124.8689 mL
5 mM 0.9990 mL 4.9948 mL 9.9895 mL 24.9738 mL
10 mM 0.4995 mL 2.4974 mL 4.9948 mL 12.4869 mL
15 mM 0.3330 mL 1.6649 mL 3.3298 mL 8.3246 mL
20 mM 0.2497 mL 1.2487 mL 2.4974 mL 6.2434 mL
25 mM 0.1998 mL 0.9990 mL 1.9979 mL 4.9948 mL
30 mM 0.1665 mL 0.8325 mL 1.6649 mL 4.1623 mL
40 mM 0.1249 mL 0.6243 mL 1.2487 mL 3.1217 mL
50 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4974 mL
60 mM 0.0832 mL 0.4162 mL 0.8325 mL 2.0811 mL
80 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5609 mL
100 mM 0.0499 mL 0.2497 mL 0.4995 mL 1.2487 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-DOPA-2,5,6-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-DOPA-2,5,6-d353587-29-4Dopamine ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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