L-Histidine-¹³C₆,¹⁵N₃,d₅ hydrochloride hydrate  (Synonyms: H-His-OH-¹³C₆,¹⁵N₃,d₅ hydrochloride hydrate)

L-Histidine-¹³C₆,¹⁵N₃,d₅ (hydrochloride hydrate) is the deuterium, ¹³C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

223.60

¹³C₆H₇D₅Cl¹⁵N₃O₃

2483829-32-7

O[13C]([13C@]([15NH2])([2H])[13C]([2H])([2H])[13C]1=[13C]([2H])[15N]=[13C]([2H])[15NH]1)=O.Cl.O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]