2. Others Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Endogenous Metabolite
  4. L-Histidine-d5 hydrochloride hydrate

L-Histidine-d5 hydrochloride hydrate  (Synonyms: H-His-OH-d5 hydrochloride hydrate)

Cat. No.: HY-W014423S4 Purity: 99.63%
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L-Histidine-d5 (hydrochloride hydrate) is the deuterium labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.

For research use only. We do not sell to patients.

L-Histidine-d<sub>5</sub> hydrochloride hydrate Chemical Structure

L-Histidine-d5 hydrochloride hydrate Chemical Structure

CAS No. : 2483831-75-8

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1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-Histidine-d5 hydrochloride hydrate:

L-Histidine-d5 hydrochloride hydrate Related Antibodies

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Description

L-Histidine-d5 (hydrochloride hydrate) is the deuterium labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Histidine-d5 hydrochloride hydrate Related Antibodies
Molecular Weight

214.66

Formula

C6H7D5ClN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@](N)([2H])C([2H])([2H])C1=C([2H])N=C([2H])N1)=O.Cl.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (582.32 mM; ultrasonic and adjust pH to 6 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6585 mL 23.2926 mL 46.5853 mL
5 mM 0.9317 mL 4.6585 mL 9.3171 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6585 mL 23.2926 mL 46.5853 mL 116.4632 mL
5 mM 0.9317 mL 4.6585 mL 9.3171 mL 23.2926 mL
10 mM 0.4659 mL 2.3293 mL 4.6585 mL 11.6463 mL
15 mM 0.3106 mL 1.5528 mL 3.1057 mL 7.7642 mL
20 mM 0.2329 mL 1.1646 mL 2.3293 mL 5.8232 mL
25 mM 0.1863 mL 0.9317 mL 1.8634 mL 4.6585 mL
30 mM 0.1553 mL 0.7764 mL 1.5528 mL 3.8821 mL
40 mM 0.1165 mL 0.5823 mL 1.1646 mL 2.9116 mL
50 mM 0.0932 mL 0.4659 mL 0.9317 mL 2.3293 mL
60 mM 0.0776 mL 0.3882 mL 0.7764 mL 1.9411 mL
80 mM 0.0582 mL 0.2912 mL 0.5823 mL 1.4558 mL
100 mM 0.0466 mL 0.2329 mL 0.4659 mL 1.1646 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Histidine-d5 hydrochloride hydrate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Histidine-d5 hydrochloride2483831-75-8H-His-OH-d5 hydrochlorideIsotope-Labeled CompoundsEndogenous MetaboliteInhibitorinhibitorinhibit

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