2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-Homocysteic acid

L-Homocysteic acid  (Synonyms: L-HCA)

Cat. No.: HY-138903 Purity: ≥98.0%
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L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.

For research use only. We do not sell to patients.

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L-Homocysteic acid Chemical Structure

L-Homocysteic acid Chemical Structure

CAS No. : 14857-77-3

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Based on 1 publication(s) in Google Scholar

L-Homocysteic acid Related Antibodies

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Description

L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3].

IC50 & Target[1]

NMDA Receptor

14 μM (EC50)

In Vitro

L-Homocysteic acid activates NMDA receptor with an EC50 value of 14 μM[1].
L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells[1].
L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction in ex vivo chick embryo retina[2].
L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Homocysteic acid Related Antibodies
In Vivo

L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development[4].
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino rats of the Wistar strain[4]
Dosage: 4, 5.5, 8, 11 mM/kg
Administration: Intraperitoneal injection, daily for 14 days
Result: Induced flexion seizures at 4 mmol/kg.
Led to intense tail flicking, pivoting, and locomotion.
Decreased ECoG (electrocorticograms) activity for 5-9 min.
Molecular Weight

183.18

Formula

C4H9NO5S
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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L-Homocysteic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Homocysteic acid14857-77-3L-HCAiGluRIonotropic glutamate receptorsExcitotoxinembryo retinaPurkinje cellsneurotoxicityhomocysteic acidseizuresneuronInhibitorinhibitorinhibit

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