DL-Homocysteine-d₄

Name: DL-Homocysteine-d 4
Brand: MedChemExpress
SKU: HY-W010347S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W010347S Purity: 98.4%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-Homocysteine-d₄ is the deuterium labeled DL-Homocysteine. DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain[1][2].

For research use only. We do not sell to patients.

DL-Homocysteine-d<sub>4</sub> Chemical Structure

DL-Homocysteine-d₄ Chemical Structure

CAS No. : 416845-90-4

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Homocysteine-d₄:

L-Homocysteine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-Homocysteine-d₄ is the deuterium labeled DL-Homocysteine. DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

139.21

Formula

C₄H₅D₄NO₂S

CAS No.

416845-90-4

Unlabeled CAS

6027-13-0

Appearance

Solid

Color

White to off-white

SMILES

SC([2H])([2H])C([2H])([2H])C(N)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (179.58 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1834 mL	35.9170 mL	71.8339 mL
5 mM	1.4367 mL	7.1834 mL	14.3668 mL
10 mM	0.7183 mL	3.5917 mL	7.1834 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.4%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. DL-Homocysteine, et al. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid. J Neurosci Res. 2005 Feb 1;79(3):375-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / H₂O / H₂O	1 mM	7.1834 mL	35.9170 mL	71.8339 mL	179.5848 mL
DMSO / DMSO / H₂O / H₂O	5 mM	1.4367 mL	7.1834 mL	14.3668 mL	35.9170 mL
H₂O / H₂O	10 mM	0.7183 mL	3.5917 mL	7.1834 mL	17.9585 mL
	15 mM	0.4789 mL	2.3945 mL	4.7889 mL	11.9723 mL
	20 mM	0.3592 mL	1.7958 mL	3.5917 mL	8.9792 mL
	25 mM	0.2873 mL	1.4367 mL	2.8734 mL	7.1834 mL
	30 mM	0.2394 mL	1.1972 mL	2.3945 mL	5.9862 mL
	40 mM	0.1796 mL	0.8979 mL	1.7958 mL	4.4896 mL
	50 mM	0.1437 mL	0.7183 mL	1.4367 mL	3.5917 mL
	60 mM	0.1197 mL	0.5986 mL	1.1972 mL	2.9931 mL
	80 mM	0.0898 mL	0.4490 mL	0.8979 mL	2.2448 mL
	100 mM	0.0718 mL	0.3592 mL	0.7183 mL	1.7958 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.